果蝇生物钟基因period影响细胞间连接通讯。
The Drosophila clock gene per affects intercellular junctional communication.
作者信息
Bargiello T A, Saez L, Baylies M K, Gasic G, Young M W, Spray D C
出版信息
Nature. 1987;328(6132):686-91. doi: 10.1038/328686a0.
DOI:10.1038/328686a0
PMID:2441265
Abstract
The per locus of Drosophila has been implicated in the control of behavioural rhythms. In fruitfly embryos and larvae per is expressed in salivary glands. Per mutations have striking effects on intercellular communication in salivary glands: gap junction channels are modulated so that their conductance varies inversely with the period of behavioural rhythms in the mutants. A similar effect on junctional communication in the nervous system may explain how per influences behavioural rhythms.
摘要
果蝇的周期基因（per）已被证明与行为节律的控制有关。在果蝇胚胎和幼虫中，周期基因在唾液腺中表达。周期基因突变对唾液腺中的细胞间通讯有显著影响：间隙连接通道受到调节，其电导与突变体行为节律的周期呈反比变化。对神经系统中连接通讯的类似影响可能解释了周期基因如何影响行为节律。
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