Sabater David, Arriarán Sofía, Romero María del Mar, Agnelli Silvia, Remesar Xavier, Fernández-López José Antonio, Alemany Marià
1] Department of Nutrition and Food Science, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain [2] Institute of Biomedicine, University of Barcelona, Barcelona 08028, Spain [3] CIBER Obesity and Nutrition, Institute of Health Carlos III, Spain.
Sci Rep. 2014 Jan 13;4:3663. doi: 10.1038/srep03663.
White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation.
白色脂肪组织（WAT）从循环葡萄糖中大量产生乳酸，尤其是在肥胖状态下；在常氧条件下，3T3L1细胞向培养基中分泌大量乳酸，同样是以葡萄糖为代价且与葡萄糖水平成比例。大部分葡萄糖被转化为乳酸，只有一部分用于合成脂肪。培养的脂肪细胞在很大程度上处于无氧状态，但这并非类似瓦伯格效应的过程。据推测，大量乳酸的产生是脂肪细胞的一种防御过程，用于处理多余的葡萄糖。通过这种方式，脂肪细胞将葡萄糖碳输出到肝脏（并减少底物供应过剩的问题），但该过程也可能是短期控制高血糖的一种机制。从雄性大鼠脂肪组织获得的体内数据与这一解释相符。
