Kutsch Jennifer, Ottinger Daniele
Neonatal Netw. 2014 Jan-Feb;33(1):19-23. doi: 10.1891/0730-0832.33.1.19.
Despite the lack of safety data, chlorhexidine gluconate (CHG) is an antiseptic with broadspectrum coverage often used in neonatal intensive care units (NICUs). Adverse skin reactions, most commonly burns, have been reported after the use of CHG. Preserving skin integrity in preterm infants is vital in the prevention of sepsis, excessive water loss, hypothermia, and renal failure.
This is a case report of two incidents of significant skin burning in extremely low birth weight (ELBW) infants who were treated with CHG for the purposes of umbilical cord sterilization prior to umbilical line placement.
This case report of burns associated with CHG in one infant weighing 610 g at birth and a second infant weighing 600 g at birth.
CHG does have a strong association with causing skin burns in the ELBW population; however, wiping the solution off of the skin seems to reduce injury.
尽管缺乏安全性数据，但葡萄糖酸氯己定（CHG）是一种具有广谱抗菌作用的防腐剂，常用于新生儿重症监护病房（NICU）。使用CHG后曾报告有皮肤不良反应，最常见的是烧伤。保护早产儿的皮肤完整性对于预防败血症、过度失水、体温过低和肾衰竭至关重要。
这是一篇病例报告，讲述了两例极低出生体重（ELBW）婴儿在放置脐静脉导管前使用CHG进行脐带消毒时出现严重皮肤烧伤的事件。
本病例报告涉及一名出生体重610克的婴儿和另一名出生体重600克的婴儿，他们均出现了与CHG相关的烧伤。
CHG与ELBW人群的皮肤烧伤有很强的关联；然而，将溶液从皮肤上擦去似乎可以减少损伤。
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