首发未用药的重性抑郁障碍与情感网络静息脑功能改变有关。
First-episode medication-naive major depressive disorder is associated with altered resting brain function in the affective network.
机构信息
The Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China ; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
The Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
出版信息
PLoS One. 2014 Jan 9;9(1):e85241. doi: 10.1371/journal.pone.0085241. eCollection 2014.
BACKGROUND
Major depressive disorder (MDD) has been associated with abnormal structure and function of the brain's affective network, including the amygdala and orbitofrontal cortex (OFC). However, it is unclear if alterations of resting-state function in this affective network are present at the initial onset of MDD.
AIMS
To examine resting-state function of the brain's affective network in first-episode, medication-naive patients with MDD compared to healthy controls (HCs).
METHODS
Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 32 first-episode, medication-naive young adult patients with MDD and 35 matched HCs. The amplitude of low-frequency fluctuations (ALFF) of the blood oxygen level-dependent (BOLD) signal and amygdala-seeded functional connectivity (FC) were investigated.
RESULTS
Compared to HC, MDD patients showed reduced ALFF in the bilateral OFC and increased ALFF in the bilateral temporal lobe extending to the insular and left fusiform cortices. Enhanced anti-correlation of activity between the left amygdala seed and the left OFC was found in MDD patients but not in HCs.
CONCLUSIONS
Reduced ALFF in the OFC suggests hypo-functioning of emotion regulation in the affective network. Enhanced anti-correlation of activity between the amygdala and OFC may reflect dysfunction of the amygdala-OFC network and additionally represent a pathological process of MDD.
背景
重度抑郁症（MDD）与大脑情感网络（包括杏仁核和眶额皮层（OFC））的结构和功能异常有关。然而，在 MDD 的初始发作时，这种情感网络的静息状态功能是否存在改变尚不清楚。
目的
与健康对照（HCs）相比，研究首发、未经药物治疗的 MDD 患者大脑情感网络的静息状态功能。
方法
对 32 名首发、未经药物治疗的年轻成年 MDD 患者和 35 名匹配的 HCs 进行静息态功能磁共振成像（rs-fMRI）。研究了血氧水平依赖（BOLD）信号的低频振幅（ALFF）和杏仁核种子的功能连接（FC）。
结果
与 HC 相比，MDD 患者双侧 OFC 的 ALFF 降低，双侧颞叶（延伸至岛叶和左侧梭状回）的 ALFF 增加。MDD 患者左杏仁核种子与左 OFC 之间的活动反相关增强，但 HCs 中未发现这种相关性。
结论
OFC 中的 ALFF 降低表明情感网络中的情绪调节功能低下。杏仁核和 OFC 之间活动的增强反相关可能反映了杏仁核-OFC 网络的功能障碍，并且是 MDD 的一个病理过程。
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