Guan Lin, Liu Rui, Wang Changshuo, Fan Qingchen, Zhou Jingjing, Wang Yun, Feng Yuan, Liu Jing, Zhou Yuan, Wang Gang, Chen Xu
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
BMC Psychiatry. 2024 Jul 31;24(1):540. doi: 10.1186/s12888-024-05977-9.
The different symptoms of major depressive disorder (MDD) in adolescents compared to adults suggested there may be differences in the pathophysiology between adolescents and adults with MDD. However, despite the amygdala being considered critical in the pathophysiology, there was limited knowledge about the commonalities and differences in the resting-state functional connectivity (rsFC) of amygdala subregions in MDD patients of different age groups.
In the current study, 65 adolescents (46 with MDD and 19 controls) and 91 adults (35 with MDD and 56 controls) were included. A seed-based functional connectivity analysis was performed for each of the amygdala subregions. A 2 × 2 ANOVA was used to analyze the main effect of age, diagnosis, and their interaction on the rsFC of each subregion.
A significant main effect of age was revealed in the rsFC of bilateral centromedial (CM) subregions and right laterobasal (LB) subregion with several brain regions in the limbic system and frontoparietal network. The significant main effect of diagnosis showed MDD patients of different ages showed higher connectivity than controls between the right LB and left middle frontal gyrus (MFG).
The rsFC of specific amygdala subregions with brain regions in the limbic system and frontoparietal network is affected by age, indicating a distinct amygdala connectivity profile in adolescents. The decreased rsFC between the right LB and the left MFG in adolescents and adults with MDD could serve as a diagnostic biomarker and a target of nonpharmacological treatment for MDD.
与成年人相比，青少年重度抑郁症（MDD）的症状有所不同，这表明青少年和成年MDD患者在病理生理学上可能存在差异。然而，尽管杏仁核被认为在病理生理学中至关重要，但对于不同年龄组的MDD患者杏仁核亚区域静息态功能连接（rsFC）的异同，人们了解有限。
在本研究中，纳入了65名青少年（46名MDD患者和19名对照）和91名成年人（35名MDD患者和56名对照）。对每个杏仁核亚区域进行基于种子点的功能连接分析。采用2×2方差分析来分析年龄、诊断及其交互作用对每个亚区域rsFC的主要影响。
在双侧中央内侧（CM）亚区域和右侧外侧基底（LB）亚区域与边缘系统和额顶网络中的几个脑区的rsFC中，发现了显著的年龄主效应。诊断的显著主效应表明，不同年龄的MDD患者右侧LB与左侧额中回（MFG）之间的连接性高于对照组。
特定杏仁核亚区域与边缘系统和额顶网络中脑区的rsFC受年龄影响，表明青少年中杏仁核连接模式独特。青少年和成年MDD患者右侧LB与左侧MFG之间rsFC的降低可作为MDD的诊断生物标志物和非药物治疗靶点。
