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JAK与类固醇受体功能的相互作用。

Interaction of JAK with steroid receptor function.

作者信息

Gupta Nibedita, Mayer Doris

机构信息

Hematology and Oncology; University Hospital Magdeburg; Magdeburg, Germany.

Hormones and Signal Transduction Group; German Cancer Research Center; Heidelberg, Germany.

出版信息

JAKSTAT. 2013 Oct 1;2(4):e24911. doi: 10.4161/jkst.24911. Epub 2013 May 7.

DOI:10.4161/jkst.24911
PMID:24416641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3881601/
Abstract

The function of steroid receptors is not only regulated by steroid hormones, but also by multiple cellular signaling cascades activated by membrane-bound receptors which are stimulated by growth factors or cytokines. Cross-talk between JAK and steroid receptors plays a central role in the regulation of a multitude of physiological processes and aberrant signaling is involved in the development of numerous diseases including cancer. In this review we provide a brief summary of the knowledge of interactions between JAK and the function of steroid receptors in normal cells and tissues and in diseases.

摘要

类固醇受体的功能不仅受类固醇激素调控，还受膜结合受体激活的多个细胞信号级联反应调控，这些膜结合受体可被生长因子或细胞因子刺激。JAK与类固醇受体之间的相互作用在众多生理过程的调节中起核心作用，异常信号传导参与包括癌症在内的多种疾病的发生发展。在本综述中，我们简要总结了JAK与类固醇受体在正常细胞、组织及疾病中的功能之间相互作用的相关知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9574/3881601/4943e768817c/jkst-2-e24911-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9574/3881601/edb61a27535b/jkst-2-e24911-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9574/3881601/4943e768817c/jkst-2-e24911-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9574/3881601/edb61a27535b/jkst-2-e24911-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9574/3881601/4943e768817c/jkst-2-e24911-g2.jpg

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