Kosan Christian, Ginter Torsten, Heinzel Thorsten, Krämer Oliver H
Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany.
Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany ; Institute of Toxicology; Medical Center of the University Mainz; Mainz, Germany.
JAKSTAT. 2013 Oct 1;2(4):e26102. doi: 10.4161/jkst.26102. Epub 2013 Aug 19.
The cytokine-inducible transcription factors signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) are important for the proper development of multicellular eukaryotes. Disturbed signaling cascades evoking uncontrolled expression of STAT5 target genes are associated with cancer and immunological failure. Here, we summarize how STAT5 acetylation is integrated into posttranslational modification networks within cells. Moreover, we focus on how inhibitors of deacetylases and tyrosine kinases can correct leukemogenic signaling nodes involving STAT5. Such small molecules can be exploited in the fight against neoplastic diseases and immunological disorders.
细胞因子诱导的转录因子信号转导子和转录激活子5A和5B（STAT5A和STAT5B）对于多细胞真核生物的正常发育至关重要。引发STAT5靶基因不受控制表达的信号级联紊乱与癌症和免疫功能衰竭相关。在此，我们总结了STAT5乙酰化如何整合到细胞内的翻译后修饰网络中。此外，我们关注去乙酰化酶和酪氨酸激酶抑制剂如何纠正涉及STAT5的致白血病信号节点。这类小分子可用于对抗肿瘤疾病和免疫紊乱。
