Mohan P K, Reddy L V, Satyanarayana N, Indira K
Arch Int Physiol Biochim. 1987 Mar;95(1):37-42. doi: 10.3109/13813458709075023.
The changes in the pattern of production and detoxification of ammonia have been studied in the skeletal muscles and blood of rats of different age groups (1, 3, 6, 12 and 24 months), subjected to exhaustive exercise. The protein profiles at exhaustion showed a sharp drop in all muscles and the decrement was more in the senile rats. In general, the muscle and blood ammonia content increased with age with a corresponding increase in AMP deaminase activity implicating the possibility of elevated purine nucleotide deamination during senescence. However, glutamate oxidation was decreased and urea and glutamine formation was increased consequent to ammonia production during senescence under intensive physical stress. The possible alterations in protein levels and ammonia production and its disposal in different skeletal muscle types of senile exhausted rats have been discussed in relation to detoxication capacity of the fibre types.
研究了不同年龄组（1、3、6、12和24个月）的大鼠在进行力竭运动后骨骼肌和血液中氨的生成和解毒模式的变化。力竭时的蛋白质谱显示所有肌肉中均急剧下降，且老年大鼠的下降幅度更大。一般来说，肌肉和血液中的氨含量随年龄增加，同时AMP脱氨酶活性相应增加，这意味着衰老过程中嘌呤核苷酸脱氨可能增加。然而，在高强度体力应激下的衰老过程中，由于氨的产生，谷氨酸氧化减少，尿素和谷氨酰胺的形成增加。结合纤维类型的解毒能力，讨论了老年力竭大鼠不同骨骼肌类型中蛋白质水平、氨生成及其处理的可能变化。
