Tabor A, Bang J, Nørgaard-Pedersen B
Br J Obstet Gynaecol. 1987 Jun;94(6):528-34. doi: 10.1111/j.1471-0528.1987.tb03145.x.
Maternal serum alpha-fetoprotein (AFP) levels were determined before and after genetic amniocentesis (n = 283) or ultrasound scan (n = 268) in a group of women participating in a randomized trial of genetic amniocentesis. Increases in AFP levels were seen significantly more often after amniocentesis than after ultrasound scan (P less than 0.001) and 48 women in the amniocentesis group had increases in AFP (delta AFP) that were larger than the maximum delta AFP (+/- 25 micrograms/l) seen in the ultrasound group. If a delta AFP of greater than 25 micrograms/l represents a feto-maternal haemorrhage (FMH) attributable to amniocentesis, the rate of amniocentesis-induced FMH was 17%. Such FMH was seen significantly more often after transplacental amniocentesis or after amniocentesis performed by less experienced operators. No association was detected between birthweight and FMH attributable to amniocentesis.
在一组参与羊膜腔穿刺术随机试验的女性中，于遗传羊膜腔穿刺术（n = 283）或超声扫描（n = 268）前后测定了母血清甲胎蛋白（AFP）水平。与超声扫描后相比，羊膜腔穿刺术后AFP水平升高的情况显著更常见（P小于0.001），并且羊膜腔穿刺术组中有48名女性的AFP升高值（AFP差值）大于超声组中所见的最大AFP差值（±25微克/升）。如果AFP差值大于25微克/升代表羊膜腔穿刺术所致的胎儿 - 母体出血（FMH），那么羊膜腔穿刺术诱发FMH的发生率为17%。这种FMH在经胎盘羊膜腔穿刺术后或由经验较少的操作人员进行羊膜腔穿刺术后显著更常见。未检测到出生体重与羊膜腔穿刺术所致FMH之间存在关联。
