Tannirandorn Y, Romayanan O
Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1999 Nov;82(11):1089-93.
Midtrimester genetic amniocentesis has become an accepted part of modern obstetric care. Although its accuracy is well established, the risk of fetomaternal hemorrhage remains controversial. This prospective study was conducted to determine how effective continuous ultrasound guided amniocentesis is in preventing fetomaternal hemorrhage. The authors investigated 30 patients undergoing midtrimester genetic amniocentesis at our institution. Amniocentesis was performed under continuous real-time ultrasound guidance using a 21-gauge, 3.5-inch long spinal needle. Maternal serum alpha-fetoprotein (AFP) levels were determined before, at 5 minutes and at 1 hour after amniocentesis. There were no significant changes in maternal serum AFP levels either at 5 minutes or at 1 hour after amniocentesis. Midtrimester genetic amniocentesis performed by a trained and experienced operator under continuous ultrasound guidance does not significantly increase the risk of fetomaternal hemorrhage after the procedure.
孕中期遗传羊膜腔穿刺术已成为现代产科护理中被认可的一部分。尽管其准确性已得到充分证实，但母胎出血的风险仍存在争议。本前瞻性研究旨在确定持续超声引导下的羊膜腔穿刺术在预防母胎出血方面的效果如何。作者对在我们机构接受孕中期遗传羊膜腔穿刺术的30例患者进行了调查。使用21号、3.5英寸长的脊椎穿刺针在持续实时超声引导下进行羊膜腔穿刺术。在羊膜腔穿刺术前、术后5分钟和1小时测定母血清甲胎蛋白（AFP）水平。羊膜腔穿刺术后5分钟或1小时母血清AFP水平均无显著变化。由训练有素且经验丰富的操作人员在持续超声引导下进行的孕中期遗传羊膜腔穿刺术，术后不会显著增加母胎出血的风险。
