正畸矫治器中金属离子的释放：动物实验
The release of metal ions from orthodontic appliances animal tests.
作者信息
Mikulewicz Marcin, Wołowiec Paulina, Janeczek Maciej, Gedrange Thomas, Chojnacka Katarzyna
机构信息
a Assistant Professor, Department of Dentofacial Orthopeadics and Orthodontics, Medical University of Wrocław, Wrocław, Poland.
出版信息
Angle Orthod. 2014 Jul;84(4):673-9. doi: 10.2319/090213-641.1. Epub 2014 Jan 13.
OBJECTIVE
To investigate the release of metal ions from an orthodontic appliance in tests on animals (pigs).
MATERIALS AND METHODS
An animal test was conducted on 24 pigs divided equally into an experimental and a control group. In total, 12 sets of experimental orthodontic plates were surgically inserted into pig snouts in the experimental group for 6 months. Noninvasive matrices (hair [0, 3, and 6 months]) and invasive matrices (kidneys, liver, lungs, aorta, and oral mucosa) were collected for multi-elemental analysis (inductively coupled plasma optical emission spectrometry) from the experimental and control groups.
RESULTS
The greatest differences in the content of toxic metals were found in the aorta (Ni level was 4.8 times higher in experimental than in the control group), in the cheek (Ni 3.5 times higher), and in the hair sampled after 3 months (Cr 3.4 times higher).
CONCLUSIONS
The obtained data indicate that the products of corrosion have passed into selected tissues of pigs; however, the doses of toxic metal ions released from the appliance did not reach toxic levels.
目的
在动物（猪）试验中研究正畸矫治器中金属离子的释放情况。
材料与方法
对24头猪进行动物试验，将其平均分为实验组和对照组。实验组通过手术将12套实验性正畸托槽植入猪的口鼻部，持续6个月。从实验组和对照组收集非侵入性基质（毛发[0、3和6个月时的样本]）和侵入性基质（肾脏、肝脏、肺、主动脉和口腔黏膜），用于多元素分析（电感耦合等离子体发射光谱法）。
结果
在主动脉（实验组镍含量比对照组高4.8倍）、脸颊（镍含量高3.5倍）以及3个月后采集的毛发（铬含量高3.4倍）中，有毒金属含量差异最大。
结论
所得数据表明，腐蚀产物已进入猪的特定组织；然而，矫治器释放的有毒金属离子剂量未达到有毒水平。
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