Moreno María Luisa, Meza Enrique, Ortega Arturo, Caba Mario
Centro de Investigaciones Biomédicas, Universidad Veracruzana , Xalapa, Veracruz , Mexico .
Chronobiol Int. 2014 May;31(4):515-22. doi: 10.3109/07420528.2013.874354. Epub 2014 Jan 13.
Rabbit pups are a natural model to study food anticipatory activity (FAA). Recently, we reported that three areas in the forebrain - the organum vasculosum of lamina terminalis, median preoptic nucleus (MnPO) and medial preoptic area - exhibit activation during FAA. Here, we examined the PER1 protein profile of these three forebrain regions in both nursed and fasted subjects. We found robust PER1 oscillations in the MnPO in nursed subjects, with high PER1 levels during FAA that persisted in fasted subjects. In conclusion, our data indicate that periodic nursing is a strong signal for PER1 oscillations in MnPO and future experiments are warranted to explore the specific role of this area in FAA.
兔幼崽是研究食物预期活动（FAA）的天然模型。最近，我们报道前脑的三个区域——终板血管器、视前正中核（MnPO）和视前内侧区——在FAA期间会出现激活。在此，我们检查了哺乳和禁食状态下这三个前脑区域的PER1蛋白谱。我们发现，哺乳状态下的MnPO中存在强烈的PER1振荡，FAA期间PER1水平较高，且在禁食状态下依然持续。总之，我们的数据表明，周期性哺乳是MnPO中PER1振荡的强烈信号，未来有必要开展实验来探究该区域在FAA中的具体作用。
