Konishi Masae, Shibuya Tomoyoshi, Mori Hiroki, Kurashita Erina, Takeda Tsutomu, Nomura Osamu, Fukuo Yuka, Matsumoto Kenshi, Sakamoto Naoto, Osada Taro, Nagahara Akihito, Ogihara Tatsuo, Watanabe Sumio
Department of Gastroenterology, Juntendo University School of Medicine , Tokyo , Japan.
Scand J Gastroenterol. 2014 Apr;49(4):501-5. doi: 10.3109/00365521.2013.873480. Epub 2014 Jan 13.
Capsule endoscopy (CE) is an established technique for the detection and diagnosis of obscure gastrointestinal bleeding (OGIB). Flexible spectral imaging color enhancement (FICE) is a software feature of RAPID 6.5. This study assessed the value of FICE for accurate identification of red lesions during CE.
We randomly selected 10 patients who underwent CE for OGIB at Juntendo University. The CE images were read by five endoscopists. Small bowel videos, which were recorded by regular CE devices (PillCam SB2, Given Imaging), were evaluated on RAPID 6.5. We standardized the reading condition to a dual view, at a speed of 20 frames/s in manual mode. This interpreted FICE-CE images obtained at settings 1-3. Both conventional and FICE images were read at random. We defined a conventional image as standard and investigated the potential of FICE in detecting small intestinal lesions by the Steel-Dwass test.
We considered that conventional images represented baseline (100). On this basis, detection rates for FICE images were as follows: FICE1 = 266.4 ± 33.1 (p < 0.0001); FICE2 = 255.4 ± 25.6 (p < 0.0001); and FICE3 = 117.0 ± 12.3 (p = 0.9447). Detection rates using FICE1 and FICE2 images were significantly higher than conventional CE images. FICE1 and FICE2 were more useful in detecting erosions than conventional CE (p < 0.0001) and FICE3 (p < 0.0001).
FICE-CE has a high level of visibility by transparentizing bile or enhancing the color difference associated with reddish mucosa. We found that FICE-CE images were useful in the diagnosing of small intestinal lesions.
胶囊内镜（CE）是检测和诊断不明原因胃肠道出血（OGIB）的既定技术。灵活光谱成像色彩增强（FICE）是RAPID 6.5的一项软件功能。本研究评估了FICE在胶囊内镜检查期间准确识别红色病变的价值。
我们随机选择了10名在顺天堂大学因OGIB接受胶囊内镜检查的患者。5名内镜医师阅读胶囊内镜图像。由常规胶囊内镜设备（PillCam SB2，Given Imaging）记录的小肠视频在RAPID 6.5上进行评估。我们将阅读条件标准化为双视图，手动模式下速度为20帧/秒。这解读了在设置1-3下获得的FICE-CE图像。常规图像和FICE图像均随机阅读。我们将常规图像定义为标准图像，并通过Steel-Dwass检验研究FICE在检测小肠病变方面的潜力。
我们认为常规图像代表基线（100）。在此基础上，FICE图像的检测率如下：FICE1 = 266.4 ± 33.1（p < 0.0001）；FICE2 = 255.4 ± 25.6（p < 0.0001）；FICE3 = 117.0 ± 12.3（p = 0.9447）。使用FICE1和FICE2图像的检测率显著高于常规胶囊内镜图像。FICE1和FICE2在检测糜烂方面比常规胶囊内镜（p < 0.0001）和FICE3（p < 0.0001）更有用。
FICE-CE通过使胆汁透明化或增强与微红黏膜相关的色差而具有较高的可视性。我们发现FICE-CE图像在诊断小肠病变方面很有用。
