Xu Ling, Zhang Peng, Zhang Ning, Yang Yong, Wu Zhi-jin, Zhang Chao-hua, Zhang Xiao-dong
Department of Urology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Department of Urology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Nov 12;93(42):3347-50.
To evaluate the efficiency of O'Leary-Sant problem index and symptom index (OPSI) in the diagnosis of interstitial cystitis (IC).
A total of 82 patients, initially diagnosed as IC, with urinary frequency, urgency and pain on pubic area during bladder filling phase from January 2008 to March 2013 were enrolled.OPSI was used to evaluate their symptoms. They were eventually divided into IC and non-IC groups according to the clinical diagnosis. The scores of OPSI, interstitial cystitis problem index (ICPI) and interstitial cystitis symptom index (ICSI) were compared between two groups. And the ROC curve was plotted to screen the diagnostic specificity and sensitivity.
Among them, 58 were diagnosed with IC and the rest with non-IC. The average score of OPSI for groups IC and non-IC were 24.7 ± 6.9 and 23.2 ± 7.8 respectively (P = 0.403). And the ICPI score for two groups were 11.7 ± 3.2 and 10.2 ± 3.7 (P = 0.070) and the ICSI score 13.0 ± 4.0 and 13.1 ± 4.3 (P = 0.975) respectively.No significant differences existed between two groups. If an OPSI score of 12 or greater for diagnosing IC, the sensitivity was 98% and specificity 8%. Because of a high sensitivity, OPSI was a useful indicator for screening IC patients from others.In the ROC curve, acreage under curve for OPSI, ICPI, ICSI were 0.548 ± 0.071, 0.622 ± 0.069 and 0.492 ± 0.070 respectively. These three indices were not good indicators for diagnosing IC.
The O'Leary-Sant symptom index and problem index has a high sensitivity but a low specificity in the diagnosis of IC. Therefore it should not be used to differentiate interstitial cystitis. A cutoff OPSI value of 12 may be used for differentiation.
评估奥利里 - 桑特问题指数和症状指数（OPSI）在间质性膀胱炎（IC）诊断中的效能。
纳入2008年1月至2013年3月期间最初诊断为IC的82例患者，这些患者在膀胱充盈期有尿频、尿急及耻骨区疼痛症状。采用OPSI评估其症状。最终根据临床诊断将他们分为IC组和非IC组。比较两组的OPSI、间质性膀胱炎问题指数（ICPI）和间质性膀胱炎症状指数（ICSI）得分。绘制ROC曲线以筛选诊断特异性和敏感性。
其中58例被诊断为IC，其余为非IC。IC组和非IC组的OPSI平均得分分别为24.7±6.9和23.2±7.8（P = 0.403）。两组的ICPI得分分别为11.7±3.2和10.2±3.7（P = 0.070），ICSI得分分别为13.0±4.0和13.1±4.3（P = 0.975）。两组间无显著差异。若以OPSI得分12分及以上诊断IC，敏感性为98%，特异性为8%。由于敏感性高，OPSI是从其他患者中筛选IC患者的有用指标。在ROC曲线中，OPSI、ICPI、ICSI的曲线下面积分别为0.548±0.071、0.622±0.069和0.492±0.070。这三个指标都不是诊断IC的良好指标。
奥利里 - 桑特症状指数和问题指数在IC诊断中敏感性高但特异性低。因此，它不应被用于鉴别间质性膀胱炎。OPSI的截断值12可用于鉴别。
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