Kushner Leslie, Moldwin Robert M
Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
J Urol. 2006 Aug;176(2):587-92. doi: 10.1016/j.juro.2006.03.035.
Questionnaires for the evaluation of interstitial cystitis are widely used, but their value in discriminating interstitial cystitis from other diagnoses among patients with urological symptoms has not been determined. We assessed the validity of 2 frequently used interstitial cystitis questionnaires-the O'Leary-Sant Symptom Index and Problem Index and the Pain, Urgency, Frequency Symptom Scale-for screening for interstitial cystitis.
The Pain, Urgency, Frequency Symptom Scale and the O'Leary-Sant Symptom Index and Problem Index were administered to the same 220 patients at a urology clinic before diagnosis. Questionnaire scores between patients with and without interstitial cystitis, as well as among diagnostic groups, were compared by parametric and nonparametric analyses. Receiver operating characteristic curves were constructed to determine the efficiency of each questionnaire in discriminating between patients with and without interstitial cystitis.
Interstitial cystitis was distinguishable from the other diagnoses using both questionnaires (p <0.001). Separate analyses of bother and symptom scores yielded similar results. Receiver operating characteristic curves demonstrated the Pain, Urgency, Frequency Symptom Scale to be more efficient than the O'Leary-Sant Symptom Index and Problem Index in detecting interstitial cystitis in this population with an optimal cutoff value of 13 or greater.
While the Pain, Urgency, Frequency Symptom Scale and the O'Leary-Sant Symptom Index and Problem Index questionnaires distinguish interstitial cystitis from other urinary tract pathologies, neither questionnaire demonstrates sufficient specificity to serve as the sole diagnostic indicator. These questionnaires should not be used to define interstitial cystitis, but can be used to screen patients with urinary tract symptoms to identify those who should be further examined for interstitial cystitis or to follow those who have already been diagnosed.
用于评估间质性膀胱炎的问卷被广泛使用，但其在有泌尿系统症状的患者中区分间质性膀胱炎与其他诊断的价值尚未确定。我们评估了两种常用的间质性膀胱炎问卷——奥利里 - 桑特症状指数和问题指数以及疼痛、尿急、尿频症状量表——用于筛查间质性膀胱炎的有效性。
在诊断前，对同一家泌尿外科诊所的220名患者进行疼痛、尿急、尿频症状量表以及奥利里 - 桑特症状指数和问题指数的评估。通过参数分析和非参数分析比较有和无间质性膀胱炎患者之间以及不同诊断组之间的问卷得分。构建受试者工作特征曲线以确定每份问卷区分有和无间质性膀胱炎患者的效率。
使用这两种问卷均可将间质性膀胱炎与其他诊断区分开来（p<0.001）。对困扰程度和症状得分进行单独分析得出了相似的结果。受试者工作特征曲线表明，在该人群中检测间质性膀胱炎时，疼痛、尿急、尿频症状量表比奥利里 - 桑特症状指数和问题指数更有效，最佳临界值为13或更高。
虽然疼痛、尿急、尿频症状量表以及奥利里 - 桑特症状指数和问题指数问卷可将间质性膀胱炎与其他尿路疾病区分开来，但这两种问卷均未显示出足够的特异性以作为唯一的诊断指标。这些问卷不应被用于定义间质性膀胱炎，但可用于筛查有尿路症状的患者，以识别那些应进一步检查是否患有间质性膀胱炎的患者，或用于随访已被诊断的患者。
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