EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
Autoimmun Rev. 2014 Apr-May;13(4-5):574-6. doi: 10.1016/j.autrev.2014.01.001. Epub 2014 Jan 11.
Autoimmune neutropenia denotes that the number of circulating polymorphonuclear neutrophils is below 1.5×10(9)/L. This encompasses a wide range of disorders from primary conditions to complications of systemic autoimmune diseases or hematological neoplasms. Antineutrophil autoantibodies are particularly difficult to detect, and their amount does not correlate with the degree of neutropenia. Granulocyte colony-stimulating factor is the first-line therapy, but should be restricted to patients with total absence of neutrophils and/or severe infections.
自身免疫性中性粒细胞减少症是指循环中的多形核中性粒细胞数量低于 1.5×10(9)/L。这包括从原发性疾病到系统性自身免疫性疾病或血液系统肿瘤并发症等广泛的疾病。抗中性粒细胞自身抗体特别难以检测，其数量与中性粒细胞减少的程度无关。粒细胞集落刺激因子是一线治疗药物，但应仅限于中性粒细胞完全缺乏和/或严重感染的患者。
