用于血清中灵敏表面等离子体共振成像免疫分析的氧化石墨烯串联信号放大技术
Graphene oxide-enabled tandem signal amplification for sensitive SPRi immunoassay in serum.
作者信息
Hu Weihua, He Guangli, Chen Tao, Guo Chun Xian, Lu Zhisong, Selvaraj Jonathan Nimal, Liu Yang, Li Chang Ming
机构信息
Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing, 400715, China.
出版信息
Chem Commun (Camb). 2014 Feb 28;50(17):2133-5. doi: 10.1039/c3cc47933a. Epub 2014 Jan 14.
PMID:24419044
Abstract
A tandem signal amplification using bioconjugated graphene oxide and subsequent silver catalytic deposition for surface plasmon resonance imaging (SPRi) to sensitively and specifically immunoassay tumor biomarkers in serum, achieving a limit of detection down to 100 pg mL(-1) with a broad dynamic range for α-Fetoprotein (AFP) is reported.
摘要
报道了一种使用生物共轭氧化石墨烯的串联信号放大以及随后的银催化沉积用于表面等离子体共振成像（SPRi），以灵敏且特异性地免疫测定血清中的肿瘤生物标志物，实现了对甲胎蛋白（AFP）低至100 pg mL⁻¹的检测限以及宽动态范围。
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