Xu Li, Wen Yanli, Pandit Santosh, Mokkapati Venkata R S S, Mijakovic Ivan, Li Yan, Ding Min, Ren Shuzhen, Li Wen, Liu Gang
1Laboratory of Biometrory, Division of Chemistry and Ionizing Radiation Measurement Technology, Shanghai Institute of Measurement and Testing Technology, Shanghai, 201203 People's Republic of China.
2Division of Systems and Synthetic Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 41126 Gothenburg, Sweden.
BMC Chem. 2019 Sep 3;13(1):112. doi: 10.1186/s13065-019-0611-x. eCollection 2019 Dec.
Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.
前列腺癌（PC）是全球第六大常见癌症类型，约占癌症总死亡人数的10%。体液中蛋白质生物标志物的检测是前列腺癌诊断和预后的关键课题。对前列腺癌进行高灵敏度筛查是降低死亡率的最有效方法。因此，越来越多的文献认识到新技术对前列腺癌早期诊断的重要性。石墨烯凭借其卓越的物理、光学、电化学和磁学性质，在生物传感器领域发挥着重要作用。最近的许多研究表明了石墨烯材料在灵敏检测蛋白质生物标志物方面的潜力。在本综述中，针对前列腺癌分析的基于石墨烯的生物传感器主要分为两类进行讨论：第一，通过将石墨烯材料修饰到传感器表面构建新型生物传感器界面。第二，利用石墨烯材料作为催化剂或载体开发巧妙的信号放大策略。基于石墨烯的生物传感器表现出了卓越的性能，具有高灵敏度、宽检测范围和长期稳定性。
