神经性厌食症中的骨代谢。
Bone metabolism in anorexia nervosa.
机构信息
Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, MA, 02114, USA,
出版信息
Curr Osteoporos Rep. 2014 Mar;12(1):82-9. doi: 10.1007/s11914-013-0186-8.
Abstract
Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is characterized by self-imposed, chronic nutritional deprivation and distorted body image. AN is associated with a number of medical comorbidities including low bone mass. The low bone mass in AN is due to an uncoupling of bone formation and bone resorption, which is the result of hormonal adaptations aimed at decreasing energy expenditure during periods of low energy intake. Importantly, the low bone mass in AN is associated with a significant risk of fractures and therefore treatments to prevent bone loss are critical. In this review, we discuss the hormonal determinants of low bone mass in AN and treatments that have been investigated in this population.
摘要
神经性厌食症（AN）是一种主要影响年轻女性的精神疾病，其特征是自我施加的、慢性的营养剥夺和扭曲的身体形象。AN 与许多医学合并症有关，包括低骨量。AN 中的低骨量是由于骨形成和骨吸收的解偶联所致，这是为了在能量摄入低的时期减少能量消耗而发生的激素适应的结果。重要的是，AN 中的低骨量与骨折的风险显著相关，因此预防骨质流失的治疗至关重要。在这篇综述中，我们讨论了 AN 中低骨量的激素决定因素以及在该人群中研究过的治疗方法。
相似文献
1
Bone metabolism in anorexia nervosa.神经性厌食症中的骨代谢。
Curr Osteoporos Rep. 2014 Mar;12(1):82-9. doi: 10.1007/s11914-013-0186-8.
2
Endocrinology of anorexia nervosa in young people: recent insights.年轻人神经性厌食症的内分泌学：最新见解。
Curr Opin Endocrinol Diabetes Obes. 2014 Feb;21(1):64-70. doi: 10.1097/MED.0000000000000026.
3
Effects of Anorexia Nervosa on Bone Metabolism.神经性厌食症对骨代谢的影响。
Endocr Rev. 2018 Dec 1;39(6):895-910. doi: 10.1210/er.2018-00063.
4
Endocrine consequences of anorexia nervosa.神经性厌食症的内分泌后果。
Lancet Diabetes Endocrinol. 2014 Jul;2(7):581-92. doi: 10.1016/S2213-8587(13)70180-3. Epub 2014 Apr 2.
5
[Bone metabolism and fracture risk in anorexia nervosa].[神经性厌食症中的骨代谢与骨折风险]
Med Clin (Barc). 2010 Jul 17;135(6):274-9. doi: 10.1016/j.medcli.2009.04.046. Epub 2009 Jul 23.
6
Neuroendocrine aspects of anorexia nervosa and bulimia nervosa.神经性厌食症和神经性贪食症的神经内分泌方面
Neuro Endocrinol Lett. 2018 Sep;39(3):172-178.
7
The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism.神经性厌食症的神经内分泌基础及其对骨代谢的影响。
Neuroendocrinology. 2011;93(2):65-73. doi: 10.1159/000323771. Epub 2011 Jan 13.
8
Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa.短期给予重组人胰岛素样生长因子I对神经性厌食症骨质疏松女性骨转换的影响。
J Clin Endocrinol Metab. 1996 Nov;81(11):3864-70. doi: 10.1210/jcem.81.11.8923830.
9
Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass.神经性厌食症患者夜间的催产素水平降低与骨密度和体脂肪量低有关。
J Clin Psychiatry. 2011 Nov;72(11):1546-51. doi: 10.4088/JCP.10m06617. Epub 2011 Aug 9.
10
Anorexia nervosa: hypogonadotrophic hypogonadism and bone mineral density.
Horm Res. 2002;57 Suppl 2:57-62. doi: 10.1159/000063953.
引用本文的文献
1
Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head.利用人类头部的T1加权图像估算骨矿物质密度和皮下脂肪含量
Imaging Neurosci (Camb). 2024 Dec 6;2. doi: 10.1162/imag_a_00390. eCollection 2024.
2
Methionine as a regulator of bone remodeling with fasting.蛋氨酸作为禁食调节骨重塑的物质。
JCI Insight. 2024 May 21;9(12):e177997. doi: 10.1172/jci.insight.177997.
3
Atraumatic Fractures in Multi-Morbid Older Adults: A Series of Five Cases and Review of Literature.多病共存的老年患者中的非创伤性骨折：五例病例系列及文献综述
Cureus. 2023 Dec 30;15(12):e51333. doi: 10.7759/cureus.51333. eCollection 2023 Dec.
4
In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.在特发性骨质疏松的绝经前妇女中，较低的骨形成率与较高的体脂肪和较高的 IGF-1 相关。
Osteoporos Int. 2022 Mar;33(3):659-672. doi: 10.1007/s00198-021-06196-8. Epub 2021 Oct 19.
5
Backstage of Eating Disorder-About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa.进食障碍的幕后——关于神经性厌食症症状背后的生物学机制。
Nutrients. 2020 Aug 27;12(9):2604. doi: 10.3390/nu12092604.
6
MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.内分泌学中的机制：神经性厌食症与内分泌学：临床更新。
Eur J Endocrinol. 2019 Jan 1;180(1):R9-R27. doi: 10.1530/EJE-18-0596.
7
Osteoporosis in Children with Chronic Illnesses: Diagnosis, Monitoring, and Treatment.儿童慢性疾病相关骨质疏松症：诊断、监测与治疗。
Curr Osteoporos Rep. 2017 Aug;15(4):271-282. doi: 10.1007/s11914-017-0371-2.
8
Eating disorders and bone metabolism in women.女性的饮食失调与骨代谢
Curr Opin Pediatr. 2017 Aug;29(4):488-496. doi: 10.1097/MOP.0000000000000508.
9
Bone-Fat Interaction.骨-脂相互作用。
Endocrinol Metab Clin North Am. 2017 Mar;46(1):41-50. doi: 10.1016/j.ecl.2016.09.004. Epub 2016 Nov 24.
10
The Association between Weight Gain/Restoration and Bone Mineral Density in Adolescents with Anorexia Nervosa: A Systematic Review.神经性厌食症青少年体重增加/恢复与骨密度之间的关联：一项系统综述
Nutrients. 2016 Nov 29;8(12):769. doi: 10.3390/nu8120769.
本文引用的文献
1
SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.SIRT1 调节生长激素-胰岛素样生长因子-I 轴在饥饿状态下的肝脏适应性反应。
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14948-53. doi: 10.1073/pnas.1220606110. Epub 2013 Aug 26.
2
The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.饥饿时生长激素的增加并不是为了维持血糖水平或瘦体重，而是雌性小鼠适当的脂肪组织反应所必需的。
Endocrinology. 2013 Jan;154(1):263-9. doi: 10.1210/en.2012-1849. Epub 2012 Nov 13.
3
The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa.性腺和肾上腺类固醇治疗对神经性厌食症青少年和年轻女性骨骼健康的影响。
Metabolism. 2012 Jul;61(7):1010-20. doi: 10.1016/j.metabol.2011.11.016. Epub 2012 Jan 16.
4
Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa.生理性雌激素替代治疗可增加神经性厌食症少女的骨密度。
J Bone Miner Res. 2011 Oct;26(10):2430-8. doi: 10.1002/jbmr.447.
5
Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study.双膦酸盐利塞膦酸钠和低剂量经皮睾酮对神经性厌食症女性骨密度的影响：一项随机、安慰剂对照研究。
J Clin Endocrinol Metab. 2011 Jul;96(7):2081-8. doi: 10.1210/jc.2011-0380. Epub 2011 Apr 27.
6
The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism.神经性厌食症的神经内分泌基础及其对骨代谢的影响。
Neuroendocrinology. 2011;93(2):65-73. doi: 10.1159/000323771. Epub 2011 Jan 13.
7
Sirtuin-1 regulation of mammalian metabolism.沉默调节蛋白1对哺乳动物新陈代谢的调控。
Trends Mol Med. 2011 Jan;17(1):8-13. doi: 10.1016/j.molmed.2010.09.005.
8
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.糖皮质激素通过单体糖皮质激素受体抑制成骨细胞分化来抑制骨形成。
Cell Metab. 2010 Jun 9;11(6):517-31. doi: 10.1016/j.cmet.2010.05.005.
9
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.酰基转移酶（GOAT）对于生长激素介导的热量限制小鼠的存活至关重要。
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7467-72. doi: 10.1073/pnas.1002271107. Epub 2010 Mar 15.
10
Anorexia nervosa, osteoporosis and circulating leptin: the missing link.神经性厌食症、骨质疏松症与循环中的瘦素：缺失的环节。
Osteoporos Int. 2010 Oct;21(10):1715-22. doi: 10.1007/s00198-009-1120-x. Epub 2010 Jan 6.
Zotero 插件