Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Neuroendocrinology. 2011;93(2):65-73. doi: 10.1159/000323771. Epub 2011 Jan 13.
Anorexia nervosa (AN) is a condition of profound undernutrition associated with alterations in various neuroendocrine axes, many of which contribute to a marked impairment in bone accrual and low bone mineral density. This review focuses on changes in the hypothalamo-pituitary-gonadal axis, the growth hormone insulin-like growth factor-1 axis, and the hypothalamo-pituitary-adrenal axis in AN, as well as alterations in various appetite-regulating hormones. In addition, the review discusses low bone mineral density and altered bone microarchitecture in AN, the pathophysiology underlying impaired bone metabolism, and possible therapeutic strategies to optimize bone health.
神经性厌食症（AN）是一种严重营养不良的病症，与各种神经内分泌轴的改变有关，其中许多轴与明显的骨积累受损和低骨矿物质密度有关。本篇综述重点介绍了 AN 中下丘脑-垂体-性腺轴、生长激素-胰岛素样生长因子-1 轴和下丘脑-垂体-肾上腺轴的变化，以及各种食欲调节激素的改变。此外，还讨论了 AN 中的低骨矿物质密度和骨微结构改变、骨代谢受损的病理生理学以及优化骨骼健康的可能治疗策略。
