有丝分裂细胞中被阻断的胞饮活性在有丝分裂-间期杂种细胞中得以恢复。

The blocked pinocytic activity of mitotic cells is restored in mitotic-interphase hybrids.

作者信息

Oliver J M, Seagrave J C

出版信息

Exp Cell Res. 1987 Aug;171(2):475-82. doi: 10.1016/0014-4827(87)90178-9.

PMID:2442020

Abstract

During mitosis there is an abrupt inhibition of a wide range of membrane functions, including fluid-phase and adsorptive pinocytosis. We have used cell hybrids formed between mitotic and interphase cells to approach the mechanism of this inhibition. We report that fluid pinocytosis is reactivated in the mitotic partner of hybrids formed between mitotic and interphase Chinese hamster ovary (CHO) cells. It thus appears that the interphase cell provides some necessary element(s) for membrane activity during mitosis. This dominance of interphase membrane properties stands in contrast with earlier evidence that mitotic nuclear properties dominate in similar mitotic-interphase hybrids.

摘要

在有丝分裂期间，包括液相胞饮作用和吸附性胞饮作用在内的多种膜功能会突然受到抑制。我们利用有丝分裂细胞和间期细胞形成的细胞杂种来探究这种抑制作用的机制。我们报告称，在有丝分裂的中国仓鼠卵巢（CHO）细胞与间期细胞形成的杂种中，有丝分裂的一方重新激活了液相胞饮作用。因此，似乎间期细胞为有丝分裂期间的膜活性提供了一些必要成分。间期膜特性的这种主导地位与早期证据形成对比，早期证据表明在类似的有丝分裂-间期杂种中，有丝分裂细胞核特性占主导。