支气管肺发育不良——三十年的发展趋势
Bronchopulmonary dysplasia - trends over three decades.
作者信息
Zysman-Colman Zofia, Tremblay Genevieve M, Bandeali Suhair, Landry Jennifer S
机构信息
Faculty of Medicine; McGill University, Montreal, Quebec.
Respiratory Epidemiology & Clinical Research Unit; McGill University, Montreal, Quebec.
出版信息
Paediatr Child Health. 2013 Feb;18(2):86-90. doi: 10.1093/pch/18.2.86.
OBJECTIVES
To describe the characteristics of bronchopulmonary dysplasia (BPD) and respiratory distress syndrome subjects, along with the trends in severity and mortality associated with BPD over the past three decades.
METHODS
Retrospective study of BPD and respiratory distress syndrome subjects born between 1980 and 2008, and admitted to Montreal Children's Hospital (Montreal, Quebec). Data were abstracted from hospital records.
RESULTS
Gestational age and birth weight were correlated with the occurrence of BPD with each additional week of gestation and 100 g in birth weight being associated with an OR of developing BPD of 0.77 and 0.89, respectively. BPD severity was associated with male sex, Apgar score and the occurrence of neonatal pneumonia. Significant trends were observed for lower mortality despite lower gestational age and birth weight, greater maternal age and multiple gestations.
CONCLUSION
Mortality from BPD has improved over the past three decades despite significant trends toward more pronounced prematurity and lower birth weights.
目的
描述支气管肺发育不良（BPD）和呼吸窘迫综合征患者的特征，以及过去三十年中与BPD相关的严重程度和死亡率趋势。
方法
对1980年至2008年间出生并入住蒙特利尔儿童医院（魁北克省蒙特利尔）的BPD和呼吸窘迫综合征患者进行回顾性研究。数据从医院记录中提取。
结果
胎龄和出生体重与BPD的发生相关，每增加一周胎龄和100克出生体重，发生BPD的OR分别为0.77和0.89。BPD严重程度与男性、阿氏评分和新生儿肺炎的发生有关。尽管胎龄和出生体重较低、母亲年龄较大及多胎妊娠，但仍观察到死亡率有显著下降趋势。
结论
尽管过去三十年中有更明显的早产和低出生体重趋势，但BPD的死亡率有所改善。
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