支气管肺发育不良对肺功能的长期影响。
Long-term impact of bronchopulmonary dysplasia on pulmonary function.
机构信息
Respiratory Epidemiology & Clinical Research Unit, McGill University, Montreal, Quebec.
出版信息
Can Respir J. 2011 Sep-Oct;18(5):265-70. doi: 10.1155/2011/547948.
BACKGROUND
Bronchopulmonary dysplasia (BPD) and the longterm respiratory consequences of prematurity are unfamiliar to adult respirologists and remain under-recognized entities to adult caregivers. In Canada, the incidence of preterm births and its main chronic respiratory complication, BPD, have increased over the past 25 years.
OBJECTIVE
To describe the posthospitalization morbidity, medication use, health care use and pulmonary function tests of a large cohort of individuals with preterm birth complicated by BPD.
METHODS
A retrospective review of the hospital records of 322 preterm infants with BPD was conducted. Outcome variables were compared across levels of disease severity. Differences between groups were tested with one-way ANOVA for continuous variables and the Mantel-Haenszel chi-squared test for ordinal variables.
RESULTS
Outcomes after the initial hospitalization that were associated with the initial severity of BPD were as follows: hospital readmissions in the first two years of life, the presence of developmental delay, forced expiratory volume in 1 s and forced vital capacity on pulmonary function tests in patients between eight and 15 years of age.
CONCLUSION
Initial BPD severity was an important predictor of pulmonary function abnormality and health care use during childhood.
背景
支气管肺发育不良（BPD）和早产儿的长期呼吸系统并发症对于成人呼吸科医生来说并不熟悉，对成人护理人员来说仍然是认识不足的问题。在加拿大，过去 25 年来，早产儿的出生率及其主要的慢性呼吸系统并发症 BPD 有所增加。
目的
描述由 BPD 复杂化的早产儿大量人群的住院后发病率、药物使用、医疗保健使用和肺功能测试。
方法
对 322 名患有 BPD 的早产儿的住院记录进行回顾性分析。根据疾病严重程度的不同对结局变量进行比较。采用单因素方差分析比较连续变量，采用曼-惠特尼 U 检验比较有序变量。
结果
与 BPD 初始严重程度相关的初始住院后结局如下：在生命的头两年中再次住院，存在发育迟缓，在 8 至 15 岁的患者中进行肺功能测试时，1 秒用力呼气量和用力肺活量异常。
结论
初始 BPD 严重程度是儿童时期肺功能异常和医疗保健使用的重要预测因素。
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