Slater J E, Kaliner M
J Allergy Clin Immunol. 1987 Sep;80(3 Pt 1):285-90. doi: 10.1016/0091-6749(87)90033-9.
A subset of patients with recurrent anaphylaxis experience ovarian hormone-related exacerbations. Symptoms in several of these women may be provoked by gonadotropins or progesterone (P) and improved by ovarian suppression, with long-term remissions noted in several patients after oophorectomy. Since adverse reactions to P might explain this association, the effects of P and estrogen on basophil histamine release from these patients were studied. Eight patients and 10 control subjects were examined. Neither estrogen nor P caused histamine release from the basophils of patients or control subjects. Moreover, anti-IgE-induced histamine release was not influenced by P or estrogen. Attempts to culture basophils for 24 hours revealed that basophil preparations from eight of 10 normal subjects but only three of eight patients retained the capacity to respond to anti-IgE after 24 hours (p = 0.088). Culture with dexamethasone reduced anti-IgE-induced histamine release in all subjects, and the possibility that P might interfere with the effect of dexamethasone was also studied. P failed to affect dexamethasone-induced reduction of basophil histamine release. Therefore, P and estradiol appear to have no effect on basophils from either patients with hormone-related exacerbations of anaphylaxis or from control subjects.
一部分复发性过敏反应患者会经历与卵巢激素相关的病情加重。其中一些女性的症状可能由促性腺激素或孕酮（P）诱发，而通过卵巢抑制可得到改善，数名患者在卵巢切除术后实现了长期缓解。由于对P的不良反应可能解释这种关联，因此研究了P和雌激素对这些患者嗜碱性粒细胞组胺释放的影响。研究了8名患者和10名对照受试者。雌激素和P均未导致患者或对照受试者的嗜碱性粒细胞释放组胺。此外，抗IgE诱导的组胺释放不受P或雌激素的影响。对嗜碱性粒细胞进行24小时培养的尝试表明，10名正常受试者中有8名的嗜碱性粒细胞制剂在24小时后仍保留对抗IgE作出反应的能力，但8名患者中只有3名如此（p = 0.088）。用地塞米松培养可降低所有受试者中抗IgE诱导的组胺释放，并且还研究了P可能干扰地塞米松作用的可能性。P未能影响地塞米松诱导的嗜碱性粒细胞组胺释放减少。因此，P和雌二醇似乎对过敏反应激素相关病情加重患者或对照受试者的嗜碱性粒细胞均无影响。
