头颈部黏膜黑色素瘤：综述

Head and neck mucosal melanoma: a review.

作者信息

Lourenço Silvia V, Fernandes Juliana D, Hsieh Ricardo, Coutinho-Camillo Claudia M, Bologna Sheyla, Sangueza Martin, Nico Marcello M S

机构信息

*Department of Pathology, Dental School, University of São Paulo, São Paulo, Brazil; †Department of Dermatology, Medical School, University Federal of Bahia, Bahia, Brazil; ‡Laboratory of Immunopathology, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil; §Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil; ¶Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil; and ‖Department of Pathology, Hospital Obrero, La Paz, Bolívia.

出版信息

Am J Dermatopathol. 2014 Jul;36(7):578-87. doi: 10.1097/DAD.0000000000000035.

DOI:10.1097/DAD.0000000000000035

PMID:24423929

Abstract

Head and neck mucosal melanoma (MM) is an aggressive and rare neoplasm of melanocytic origin. To date, few retrospective series and case reports have been reported on MM. This article reviews the current evidence on head and neck MM and the molecular pathways that mediate the pathogenesis of this disease. Head and neck MM accounts for 0.7%-3.8% of all melanomas and involve (in decreasing order of frequency) the sinonasal cavity, oral cavity, pharynx, larynx, and upper esophagus. Although many studies have examined MM of the head and neck and the underlying molecular pathways, individual genetic and molecular alterations were less investigated. Further studies are needed to complement existing data and to increase our understanding of melanocytes tumorigenesis.

摘要

头颈部黏膜黑色素瘤（MM）是一种起源于黑素细胞的侵袭性罕见肿瘤。迄今为止，关于MM的回顾性系列研究和病例报告较少。本文综述了目前关于头颈部MM的证据以及介导该疾病发病机制的分子途径。头颈部MM占所有黑色素瘤的0.7%-3.8%，累及（按频率递减顺序）鼻腔、口腔、咽、喉和上食管。尽管许多研究已经对头颈部MM及其潜在分子途径进行了研究，但对个体遗传和分子改变的研究较少。需要进一步的研究来补充现有数据，并增进我们对黑素细胞肿瘤发生的理解。