Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio.
Division of Hematology and Oncology and Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio.
J Am Acad Dermatol. 2014 Aug;71(2):366-75. doi: 10.1016/j.jaad.2014.03.031. Epub 2014 May 6.
Mucosal melanomas are aggressive cancers of mucosal surfaces with clinical and pathologic characteristics distinct from cutaneous melanomas, warranting different staging systems and treatment approaches. Surgical resection is performed frequently for the primary tumor, although the utility of lymph node surgery and radiation therapy is not established. Therapies targeted against C-KIT activating mutations, identified in many mucosal melanomas, are emerging as promising treatments.
黏膜黑色素瘤是一种侵袭性的黏膜表面癌症，其临床和病理特征与皮肤黑色素瘤明显不同，因此需要不同的分期系统和治疗方法。尽管淋巴结手术和放疗的效果尚未确定，但经常对原发性肿瘤进行手术切除。针对许多黏膜黑色素瘤中发现的 C-KIT 激活突变的靶向治疗方法正在成为有前途的治疗方法。
