Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
Fertil Steril. 2014 Mar;101(3):805-11. doi: 10.1016/j.fertnstert.2013.11.122. Epub 2014 Jan 11.
To describe the outcomes of electroejaculation (EEJ) and testicular sperm extraction (TESE) performed for fertility preservation among male patients who are unable to ejaculate or have nonobstructive azoospermia/severe oligospermia before definitive cancer therapy.
Retrospective cohort study.
Tertiary cancer referral center.
PATIENT(S): Forty-nine patients seeking fertility preservation before definitive cancer therapy, with anejaculation, religious or cultural objections to masturbation, azoospermia, or severe oligospermia requiring either EEJ or TESE.
INTERVENTION(S): EEJ and TESE.
MAIN OUTCOME MEASURE(S): Sperm retrieval rates.
RESULT(S): Fifty-nine percent of patients overall and 60% of adolescents/young adults had sperm retrieved for cryopreservation. EEJ was successful in retrieving sperm in 60% of adolescents. Of all adolescents and young adults undergoing TESE, 33% had sperm retrieved for cryopreservation. No complications were reported. Chemotherapy was commenced without delay in all patients requiring it, frequently on the same day as the sperm retrieval.
CONCLUSION(S): EEJ and TESE can be safely and successfully used for fertility preservation before cancer therapy among boys and young adult men who are unable to provide a semen specimen or have nonobstructive azoospermia, and they should be considered in all men meeting this patient profile.
描述在接受确定性癌症治疗前无法射精或患有非梗阻性无精子症/严重少精子症的男性患者中，为了生育保存而进行电刺激射精（EEJ）和睾丸精子提取（TESE）的结果。
回顾性队列研究。
三级癌症转诊中心。
49 名在接受确定性癌症治疗前寻求生育保存的患者，存在无法射精、出于宗教或文化原因反对自慰、无精子症或严重少精子症，需要进行 EEJ 或 TESE。
EEJ 和 TESE。
精子获取率。
总体而言，59%的患者和 60%的青少年/年轻男性成功获取精子进行冷冻保存。EEJ 成功获取精子的比例为 60%的青少年。所有接受 TESE 的青少年和年轻男性中，有 33%的人获取精子进行冷冻保存。未报告任何并发症。所有需要化疗的患者均未延迟开始化疗，通常在精子获取的同一天开始。
EEJ 和 TESE 可安全、有效地用于无法提供精液样本或患有非梗阻性无精子症的男孩和年轻成年男性在癌症治疗前的生育保存，应考虑在所有符合该患者特征的男性中使用。
