Tunsaringkarn Tanasorn, Zapuang Kalaya, Rungsiyothin Anusorn
College of Public Health Sciences, Chulalongkorn University, Institute Building 2-3, Soi Chulalongkorn 62 Phyathai Rd., Bangkok, 10330 Thailand.
Indian J Clin Biochem. 2013 Oct;28(4):396-402. doi: 10.1007/s12291-013-0322-3. Epub 2013 Apr 3.
Cholinesterase is one of many important enzymes needed for acetylcholine hydrolysis. This study aimed to evaluate the serum pseudo-cholinesterase (BuChE) level and its relation to biological parameters (hematological and biochemical parameters) and symptoms among occupational workers, gasoline station worker in Bangkok, Thailand. Our results revealed that the average BuChE level was in normal range, but it had strong relation to hemoglobin (Hb), hematocrit (Hct), blood urea nitrogen (BUN), creatinine (Cr) and serum glutamic pyruvic trans-aminase (SGPT) (Linear regression analysis, p < 0.05, p < 0.05, p < 0.01, p = 0.001 and p < 0.01 respectively). Although, BuChE was not related to white blood cell parameters, but it may exhibit the skin irritation (p = 0.058) of the workers as it showed significant correlation to conjunctivitis and nausea (Pearson's correlation, p < 0.01 and p < 0.05). In conclusion, this finding may explain that BuChE was significantly related to red blood cells (RBC), liver and kidney functions.
胆碱酯酶是乙酰胆碱水解所需的多种重要酶之一。本研究旨在评估泰国曼谷加油站职业工人血清假性胆碱酯酶（BuChE）水平及其与生物学参数（血液学和生化参数）和症状之间的关系。我们的结果显示，BuChE平均水平在正常范围内，但它与血红蛋白（Hb）、血细胞比容（Hct）、血尿素氮（BUN）、肌酐（Cr）和血清谷丙转氨酶（SGPT）有很强的相关性（线性回归分析，p分别<0.05、<0.05、<0.01、=0.001和<0.01）。虽然BuChE与白细胞参数无关，但它可能表现出工人的皮肤刺激（p = 0.058），因为它与结膜炎和恶心有显著相关性（Pearson相关性，p < 0.01和p < 0.05）。总之，这一发现可能解释了BuChE与红细胞（RBC）、肝脏和肾脏功能显著相关。
