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体外循环冠状动脉旁路移植术中主动脉内注射肾上腺素成功抢救 CO2 栓塞致心跳骤停-病例报告-。

Successful resuscitation of cardiac arrest caused by CO2 embolism with intra-aortic injection of epinephrine during off-pump coronary bypass surgery -a case report-.

机构信息

Department of Anesthesiology and Pain Medicine, Inha University College of Medicine, Incheon, Korea.

Department of Anesthesiology and Pain Medicine, and Anesthesia and Pain Research institute, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Korean J Anesthesiol. 2013 Dec;65(6):562-4. doi: 10.4097/kjae.2013.65.6.562. Epub 2013 Dec 26.

DOI:10.4097/kjae.2013.65.6.562
PMID:24427464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3888851/
Abstract

Although compressed gas (CO2) blowers have been used safely to aid accurate grafting during off-pump coronary bypass surgery, hemodynamic collapse due to gas embolism into the right coronary artery may occur. Supportive measures to facilitate gas clearance by increasing the coronary perfusion pressure have been reported to be successful in restoring hemodynamic stability. However, right ventricular dysfunction and atrioventricular nodal ischemia may hinder effective systemic delivery of the vasoactive medications, even when performing resuscitative measures such as direct cardiac massage. We herein report a case of cardiac arrest that was caused by a right coronary gas embolism and that could not be restored by cardiac resuscitation. When supportive measures fail, direct aortic injection of epinephrine to increase the coronary perfusion pressure can be attempted before initiating cardiopulmonary bypass, and this approach may be life-saving in situations that limit systemic drug delivery from the venous side despite the performance of direct cardiac massage.

摘要

虽然在非体外循环冠状动脉旁路移植术中使用压缩气体(CO2)吹气机来辅助精确吻合是安全的,但气体栓塞进入右冠状动脉可能导致血液动力学崩溃。据报道,通过增加冠状动脉灌注压来支持清除气体的措施可成功恢复血液动力学稳定性。然而,右心室功能障碍和房室结缺血可能会阻碍血管活性药物的有效全身输送,即使在进行复苏措施(如直接心脏按摩)时也是如此。我们在此报告一例由右冠状动脉气体栓塞引起的心脏骤停病例,该病例无法通过心脏复苏恢复。当支持措施失败时,在开始体外循环之前,可以尝试直接向主动脉内注射肾上腺素以增加冠状动脉灌注压,在即使进行直接心脏按摩,从静脉侧全身输送药物也受到限制的情况下,这种方法可能具有救命作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b54b/3888851/e7207c96d6e1/kjae-65-562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b54b/3888851/e7207c96d6e1/kjae-65-562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b54b/3888851/e7207c96d6e1/kjae-65-562-g001.jpg

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本文引用的文献

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Gaseous emboli during off-pump surgery with T-graft technique, two different mechanisms.采用T型移植物技术的非体外循环手术期间的气体栓子,两种不同机制。
Interact Cardiovasc Thorac Surg. 2010 May;10(5):766-9. doi: 10.1510/icvts.2009.228270. Epub 2010 Feb 12.
2
Carbon dioxide embolism induced right coronary artery ischaemia during off-pump obtuse marginalis artery grafting.非体外循环下钝缘支动脉桥接术时发生二氧化碳栓塞导致右冠状动脉缺血。
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Aborted off-pump coronary artery bypass patients have much worse outcomes than on-pump or successful off-pump patients.
非体外循环冠状动脉搭桥手术失败的患者比接受体外循环手术或非体外循环手术成功的患者预后差得多。
Circulation. 2005 Aug 30;112(9 Suppl):I332-7. doi: 10.1161/CIRCULATIONAHA.104.526228.
4
Aortic arch versus central venous epinephrine during CPR.心肺复苏期间主动脉弓注射与中心静脉注射肾上腺素的比较
Ann Emerg Med. 1993 Apr;22(4):703-8. doi: 10.1016/s0196-0644(05)81852-9.
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A new proposal of CPR based on coronary perfusion pressure.
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