Numajiri Maki, Nishizawa Daisuke, Ikeda Kazutaka, Yoshihara Eiji, Iwahashii Kazuhiko
Laboratory of Neurophysiology, the Graduate School of Environmental Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
Research Project for Addictive Substances, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Toukyo 156-8506, Japan.
Nihon Arukoru Yakubutsu Igakkai Zasshi. 2013 Oct;48(5):293-9.
As a help of the mechanism elucidation of nicotine dependence, we studied the relationship between glycogen synthase kinase (GSK) - 3beta -1727A/T and -50T/C genetic polymorphisms, which are reported to be related to bipolar disorder. We genotyped the two polymorphisms in the GSK-3beta gene using a polymerase chain reaction (PCR) in 103 healthy controls (never smokers) and 71 smokers with FTND scores of 3 or above. There is no significant relationship between the polymorphism of GSK-3beta -1727A/T and the nicotine addicts. However, it was shown that GSK-3beta -50T/C polymorphism was significantly associated with the nicotine dependence. There was significantly lower T-allele frequency in the smokers than controls (chi2 (2) = 23.42, P = 0.01; chi2 (1) = 12.17, P = 0.01).
为了辅助阐明尼古丁依赖的机制，我们研究了糖原合酶激酶（GSK）-3β -1727A/T和-50T/C基因多态性之间的关系，据报道这两种多态性与双相情感障碍有关。我们使用聚合酶链反应（PCR）对103名健康对照者（从不吸烟者）和71名FTND评分在3分及以上的吸烟者的GSK-3β基因中的这两种多态性进行基因分型。GSK-3β -1727A/T多态性与尼古丁成瘾者之间没有显著关系。然而，研究表明GSK-3β -50T/C多态性与尼古丁依赖显著相关。吸烟者中的T等位基因频率显著低于对照组（χ2(2)=23.42，P = 0.01；χ2(1)=12.17，P = 0.01）。
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