双相情感障碍锂盐治疗反应者与无反应者中GSK - 3β基因多态性的单倍型分析
Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders and nonresponders.
作者信息
Iwahashi Kazuhiko, Nishizawa Daisuke, Narita Shin, Numajiri Maki, Murayama Ohoshi, Yoshihara Eiji, Onozawa Yuuya, Nagahori Kenta, Fukamauchi Fumihiko, Ikeda Kazutaka, Ishigooka Jun
机构信息
*Laboratory of Physiology, Psychophysiology/Psychiatry Project, the Graduate School of Environmental Health, and †Health Administration Center, Azabu University, Sagamihara; ‡Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science; §Department of Neuropsychiatry, Tokyo Women's Medical University, Tokyo; ∥Laboratory of Molecular Biology, School of Life and Environmental Science, Azabu University, Sagamihara; and ¶Enomoto Clinic, Tokyo, Japan.
出版信息
Clin Neuropharmacol. 2014 Jul-Aug;37(4):108-10. doi: 10.1097/WNF.0000000000000039.
The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B -50T/C and -1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders.The distributions of the GSK3B haplotypes (-50T/C and -1727A/T) showed a trend for significant difference between the lithium nonresponders and responders (global P=0.07074). Haplotype 1 (T-A) was associated with a higher lithium response (haplotype-specific P=0.03477), whereas haplotype 2 (C-A) was associated with a lower lithium response (haplotype-specific P=0.03443).The pairwise D' and r values between the 2 SNPs in this study were 1.0 and 0.097, respectively. The 2 SNPs showed weak linkage disequilibrium with each other.
GSK-3β基因（GSK3B）编码一种酶，该酶是心境稳定剂锂盐以及可能还有丙戊酸作用的靶点。在本研究中，我们在日本双相情感障碍锂盐治疗无反应者和有反应者中，研究了由GSK3B -50T/C和-1727A/T单核苷酸多态性（SNP）组成的单倍型与锂盐疗效之间的关系。GSK3B单倍型（-50T/C和-1727A/T）的分布在锂盐治疗无反应者和有反应者之间显示出显著差异的趋势（总体P = 0.07074）。单倍型1（T-A）与较高的锂盐反应相关（单倍型特异性P = 0.03477），而单倍型2（C-A）与较低的锂盐反应相关（单倍型特异性P = 0.03443）。本研究中这两个SNP之间的成对D'和r值分别为1.0和0.097。这两个SNP彼此显示出弱连锁不平衡。
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