Jung Young-Suk, Shin Min-Ho, Kweon Sun-Seog, Lee Young-Hoon, Kim Ok-Joon, Kim Young-Joon, Chung Hyun-Ju, Kim Ok-Su
Department of Periodontology, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju, South Korea.
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Gerodontology. 2015 Dec;32(4):267-73. doi: 10.1111/ger.12107. Epub 2014 Jan 16.
To investigate the association of periodontal disease and the number of teeth present with the risk of prediabetes and diabetes as well as with blood glucose and HbA1c levels in adult Koreans.
The relationship between periodontal disease and diabetes has not been fully elucidated.
Cross-sectional data from 5535 participants aged ≥50 years were obtained from 2008 to 2010. Periodontal status was measured as pocket depth (PD), clinical attachment loss (CAL) and bleeding on probing (BOP) recorded. The percentage of sites with a PD ≥4 mm, CAL ≥4 mm (CAL4) and BOP (BOP%) were recorded. Participants were divided into three groups according to PD4, CAL4 and BOP% measurements. Number of teeth present was divided into four groups. Participants were classified as normoglycaemic, prediabetic or diabetic based on HbA1c and fasting glucose levels.
After full adjustment, the highest tertile of CAL4 (OR: 1.47, 95% CI: 1.18-2.02, p < 0.001), PD4 (OR: 1.58, 95% CI: 1.26-1.97, p < 0.001) and BOP% (OR: 1.37, 95% CI: 1.07-1.75, p = 0.012) had significantly increased odds of diabetes. The number of teeth present was inversely related to diabetes (p < 0.001) and prediabetes (p = 0.032) risk. Periodontal disease severity was positively associated with HbA1c and glucose levels. The number of teeth present was positively associated with HbA1c, but not glucose, levels.
Periodontal disease and the number of teeth present are associated with an increased risk of diabetes and increased blood glucose and HbA1c levels in Koreans aged ≥50 years.
调查韩国成年人牙周疾病、现存牙齿数量与糖尿病前期及糖尿病风险以及血糖和糖化血红蛋白（HbA1c）水平之间的关联。
牙周疾病与糖尿病之间的关系尚未完全阐明。
获取了2008年至2010年5535名年龄≥50岁参与者的横断面数据。测量牙周状况，记录牙周袋深度（PD）、临床附着丧失（CAL）和探诊出血（BOP）情况。记录PD≥4mm、CAL≥4mm（CAL4）和BOP（BOP%）部位的百分比。根据PD4、CAL4和BOP%测量结果将参与者分为三组。现存牙齿数量分为四组。根据HbA1c和空腹血糖水平将参与者分类为血糖正常、糖尿病前期或糖尿病患者。
经过全面调整后，CAL4最高三分位数（比值比：1.47，95%置信区间：1.18 - 2.02，p < 0.001）、PD4（比值比：1.58，95%置信区间：1.26 - 1.97，p < 0.001）和BOP%（比值比：1.37，95%置信区间：1.07 - 1.75，p = 0.012）患糖尿病的几率显著增加。现存牙齿数量与糖尿病（p < 0.001）和糖尿病前期（p = 0.032）风险呈负相关。牙周疾病严重程度与HbA1c和血糖水平呈正相关。现存牙齿数量与HbA1c水平呈正相关，但与血糖水平无关。
牙周疾病和现存牙齿数量与≥50岁韩国人患糖尿病风险增加以及血糖和HbA1c水平升高有关。
