Yamamoto Yuko, Morozumi Toshiya, Hirata Takahisa, Takahashi Toru, Fuchida Shinya, Toyoda Masami, Nakajima Shigeru, Minabe Masato
Department of Dental Hygiene, Kanagawa Dental University, Junior College, 82 Inaoka, Yokosuka 2388580, Kanagawa, Japan.
Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka 2388580, Kanagawa, Japan.
J Clin Med. 2020 Oct 9;9(10):3234. doi: 10.3390/jcm9103234.
Both periodontal disease and diabetes are common chronic inflammatory diseases. One of the major problems with type 2 diabetes is that unregulated blood glucose levels damage the vascular endothelium and cause complications. A bidirectional relationship between periodontal disease and diabetic complications has been reported previously. However, whether periodontal disease affects the presence of diabetic complications has not been clarified. Therefore, we examined the effect of the periodontal disease status on diabetic complications in patients with type 2 diabetes. Periodontal doctors examined the periodontal disease status of 104 type 2 diabetic patients who visited a private diabetes medical clinic once a month between 2016 and 2018. The subject's diabetic status was obtained from their medical records. Bayesian network analysis showed that bleeding on probing directly influenced the presence of diabetic retinopathy in type 2 diabetes patients. In addition, bleeding on probing was higher in the diabetic retinopathy group ( = 36) than in the group without diabetic retinopathy ( = 68, = 0.006, Welch's -test). Bleeding on probing represents gingival inflammation, which might affect the presence of diabetic retinopathy in type 2 diabetes patients who regularly visit diabetic clinics.
牙周病和糖尿病都是常见的慢性炎症性疾病。2型糖尿病的主要问题之一是血糖水平失控会损害血管内皮并引发并发症。先前已有报道称牙周病与糖尿病并发症之间存在双向关系。然而，牙周病是否会影响糖尿病并发症的发生尚未明确。因此，我们研究了牙周病状况对2型糖尿病患者糖尿病并发症的影响。牙周科医生检查了2016年至2018年期间每月前往一家私立糖尿病诊所就诊的104例2型糖尿病患者的牙周病状况。受试者的糖尿病状况来自他们的病历。贝叶斯网络分析表明，探诊出血直接影响2型糖尿病患者糖尿病视网膜病变的发生。此外，糖尿病视网膜病变组（=36）的探诊出血率高于无糖尿病视网膜病变组（=68，=0.006，韦尔奇t检验）。探诊出血代表牙龈炎症，这可能会影响定期就诊糖尿病诊所的2型糖尿病患者糖尿病视网膜病变的发生。
