Department of Periodontology, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju, South Korea.
J Clin Periodontol. 2014 Mar;41(3):262-8. doi: 10.1111/jcpe.12204. Epub 2013 Dec 22.
We assessed the association of periodontal disease and number of missing teeth with subclinical atherosclerosis in an adult Korean population.
Cross-sectional data from 5404 individuals aged ≥50 years were obtained from the 2008-2010 Dong-gu study. Periodontal examinations were conducted to determine the number of missing teeth, pocket depth (PD), clinical attachment loss (CAL), and bleeding on probing (BOP). The percentages of sites with PD ≥ 4 mm (PD 4%), CAL ≥ 4 mm (CAL 4%), and BOP (BOP%) were recorded for each participant. B-mode ultrasound was performed to determine common carotid artery intima-media thickness (CCA IMT) and the presence of carotid plaques. Multivariate linear regression models were used to assess the associations between periodontal parameters and CCA IMT and carotid plaque.
Number of missing teeth was associated with increased CCA IMT, and BOP% was associated with increased CCA IMT in females only. This association was robust in never smokers.
The number of missing teeth was associated with CCA IMT, and BOP% was associated with CCA IMT in females only. These associations were robust in never smokers. Our results suggest that tooth loss due to oral disease may play a role in subclinical carotid atherosclerosis.
我们评估了在韩国成年人群中牙周病和失牙数量与亚临床动脉粥样硬化之间的关系。
本研究数据来自于 2008-2010 年东九研究的 5404 名年龄≥50 岁的个体的横断面数据。通过牙周检查来确定失牙数量、探诊深度（PD）、临床附着丧失（CAL）和探诊出血（BOP）。记录每位参与者 PD≥4mm（PD4%）、CAL≥4mm（CAL4%）和 BOP（BOP%）的位点百分比。采用 B 型超声检测颈总动脉内膜中层厚度（CCA IMT）和颈动脉斑块的存在。采用多变量线性回归模型来评估牙周参数与 CCA IMT 和颈动脉斑块之间的关系。
失牙数量与 CCA IMT 增加相关，BOP%仅与女性的 CCA IMT 增加相关。这种关联在从不吸烟者中是稳健的。
失牙数量与 CCA IMT 相关，BOP%仅与女性的 CCA IMT 相关。这些关联在从不吸烟者中是稳健的。我们的研究结果表明，口腔疾病导致的牙齿缺失可能在亚临床颈动脉粥样硬化中起作用。
