State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
BMC Med Genet. 2014 Jan 16;15:8. doi: 10.1186/1471-2350-15-8.
Previous epidemiological studies have presented conflicting evidence regarding associations between interleukin-1 (IL-1) polymorphisms and sepsis susceptibility. We have performed a meta-analysis to evaluate possible associations between IL-1 polymorphisms and sepsis risk.
Eligible literature was retrieved from PubMed, Embase and Web of Knowledge databases until Jun 15, 2013. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random-effects model in the overall and subgroup analysis based on ethnicity, sepsis severity and quality score.
Eighteen studies addressing five IL-1 polymorphisms were included in this meta-analysis. For IL-1A-889 (rs1800587) polymorphism, significant association was observed in overall comparison for allelic effect (OR = 1.47, 95% CI = 1.01-2.13, P = 0.04). There were no significant associations between either IL-1B-511 (rs16944) or IL-1B-31 (rs1143627) and sepsis susceptibility in overall or subgroup analyses. For IL-1B + 3594 (rs143634) polymorphism, genotype TT decreased sepsis risk in overall analysis (OR = 0.59, 95% CI = 0.36-0.97, P = 0.04), as well as in Caucasian (OR = 0.57, 95% CI = 0.34-0.95, P = 0.03) and sepsis (OR = 0.55, 95% CI = 0.31-0.97, P = 0.04) subgroup analysis. For IL-1RN VNTR polymorphism, significant association was observed in overall comparison for allelic effect (OR = 1.40, 95% CI = 1.01-1.95, P = 0.04). Furthermore, the effect sizes of IL-1RN VNTR on sepsis risk increased with disease severity (septic shock OR > severe sepsis OR > sepsis OR).
Our meta-analysis indicated that IL-1A-889, IL-1B + 3954 and IL-1RN VNTR might be associated with sepsis susceptibility. However, further studies with larger sample sizes and from homogenous populations would be necessary to validate these findings.
先前的流行病学研究对白细胞介素-1（IL-1）多态性与脓毒症易感性之间的关联提供了相互矛盾的证据。我们进行了荟萃分析，以评估 IL-1 多态性与脓毒症风险之间的可能关联。
从 PubMed、Embase 和 Web of Knowledge 数据库中检索到符合条件的文献，检索时间截至 2013 年 6 月 15 日。根据种族、脓毒症严重程度和质量评分，使用随机效应模型对总体和亚组分析中 IL-1 多态性与脓毒症风险的合并优势比（OR）和 95%置信区间（CI）进行计算。
该荟萃分析共纳入了 18 项研究，涉及 5 种 IL-1 多态性。对于 IL-1A-889（rs1800587）多态性，等位基因效应的总体比较存在显著关联（OR = 1.47，95%CI = 1.01-2.13，P = 0.04）。IL-1B-511（rs16944）或 IL-1B-31（rs1143627）与脓毒症易感性之间在总体或亚组分析中均无显著关联。对于 IL-1B+3594（rs143634）多态性，基因型 TT 降低了总体分析中的脓毒症风险（OR = 0.59，95%CI = 0.36-0.97，P = 0.04），以及在白种人（OR = 0.57，95%CI = 0.34-0.95，P = 0.03）和脓毒症（OR = 0.55，95%CI = 0.31-0.97，P = 0.04）亚组分析中。对于 IL-1RN VNTR 多态性，等位基因效应的总体比较存在显著关联（OR = 1.40，95%CI = 1.01-1.95，P = 0.04）。此外，IL-1RN VNTR 对脓毒症风险的影响大小随着疾病严重程度的增加而增加（脓毒性休克 OR > 严重脓毒症 OR > 脓毒症 OR）。
本荟萃分析表明，IL-1A-889、IL-1B+3954 和 IL-1RN VNTR 可能与脓毒症易感性相关。然而，需要更大样本量和来自同质人群的进一步研究来验证这些发现。
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