Department of Pediatric Oncology, The First Hospital of Jilin University, Changchun, China.
Department of Burn Surgery, The First Hospital of Jilin University, Changchun, China.
Neurol Sci. 2018 Sep;39(9):1529-1536. doi: 10.1007/s10072-018-3449-4. Epub 2018 May 28.
The aim of the current study was to clarify the role of four common genetic polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures (FS) by means of meta-analyses. We searched for studies published until February 2018 using ISI Web of Science, Pubmed, Wanfang, and Chinese National Knowledge Infrastructure databases. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using MetaAnalyst version Beta 3.13. Seventeen case-control studies were included for meta-analysis. For the IL-1B rs16944 polymorphism, the summary analysis of studies conducted among Caucasian populations showed a significant association in the CT+TT versus CC contrast (OR 1.434, 95% CI 1.153-1.785), while the pooled analysis for Asian populations yielded a significant estimate in the TT versus CC+CT comparison (OR 1.393, 95% CI 1.051-1.846). No association was observed between the IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms and FS risk. Sensitivity analyses excluding studies showing deviation from Hardy-Weinberg equilibrium did not alter conclusions. The findings of our meta-analysis suggest that the IL-1B rs16944 polymorphism may be an important genetic determinant for FS in Caucasian and Asian populations.
本研究旨在通过荟萃分析阐明白细胞介素-1β（IL-1β）和白细胞介素-1α（IL-1A）基因中四种常见遗传多态性在发热性惊厥（FS）风险中的作用。我们使用 ISI Web of Science、Pubmed、万方和中国国家知识基础设施数据库检索了截至 2018 年 2 月发表的研究。使用 MetaAnalyst 版本 Beta 3.13 计算汇总优势比（OR）和 95％置信区间（CI）。共有 17 项病例对照研究进行荟萃分析。对于 IL-1B rs16944 多态性，在高加索人群中进行的研究汇总分析显示，在 CT+TT 与 CC 对照中存在显著相关性（OR 1.434，95％CI 1.153-1.785），而亚洲人群的汇总分析显示 TT 与 CC+CT 比较中存在显著估计值（OR 1.393，95％CI 1.051-1.846）。IL-1B rs1143627、IL-1B rs1143634 和 IL-1A rs1800587 多态性与 FS 风险之间无关联。排除不符合 Hardy-Weinberg 平衡的研究进行敏感性分析并未改变结论。荟萃分析的结果表明，IL-1B rs16944 多态性可能是高加索人和亚洲人群 FS 的重要遗传决定因素。
