John M. Benson, Pharm.D., is Director of Pharmacy, Promise Hospital of Salt Lake, Salt Lake City, UT, and Adjunct Associate Professor, College of Pharmacy, University of Utah, Salt Lake City (
Am J Health Syst Pharm. 2014 Feb 1;71(3):227-30. doi: 10.2146/ajhp130321.
The impact on antimicrobial costs of an antimicrobial stewardship program (ASP) that integrated pharmacy students as integral members was evaluated.
Demographic and discharge disposition data and antimicrobial acquisition cost data were retrospectively collected for all patients admitted to Promise Hospital of Salt Lake between June 1, 2009, and May 31, 2012. During this study, the primary role of pharmacy students in the ASP was to monitor all infection-related patient problems in the facility and meet daily with the infectious diseases pharmacist and clinical pharmacist to develop recommendations for optimizing antimicrobial use. The primary outcome measure was the mean antimicrobial acquisition cost per patient per day, calculated before ASP implementation (baseline period) and two years after ASP implementation (intervention period). The acquisition costs of antimicrobial agents per patient day were compared before and two years after implementation of the ASP involving pharmacy students. Statistical significance was determined using Student's t test for continuous data and the chi-square test for nominal data.
The rate of patient discharge to skilled nursing facilities was significantly higher during the intervention period versus the baseline period (p = 0.016); no other significant comparisons were found. The mean ± S.D. antimicrobial costs per patient day were $75.37 ± $11.85 in the baseline period and $64.13 ± $13.78 in the intervention period (p = 0.022). This difference represents a cost savings of $261,630 during the two-year intervention period.
Decreased antimicrobial costs were observed over a two-year period after implementation of an ASP that incorporated pharmacy students as integral members of the program.
评估将药学学生作为不可或缺的成员纳入抗菌药物管理计划（ASP）对抗菌药物成本的影响。
回顾性收集 2009 年 6 月 1 日至 2012 年 5 月 31 日期间所有入住盐湖诺言医院患者的人口统计学和出院情况数据以及抗菌药物获取成本数据。在这项研究中，药学学生在 ASP 中的主要角色是监测医疗机构中所有与感染相关的患者问题，并与传染病药剂师和临床药剂师每天会面，制定优化抗菌药物使用的建议。主要观察指标是计算每位患者每天的平均抗菌药物获取成本，在 ASP 实施之前（基线期）和实施两年后（干预期）进行。比较 ASP 实施前后（包括药学学生参与）每位患者每天的抗菌药物获取成本。使用学生 t 检验比较连续数据，使用卡方检验比较名义数据。
干预期患者出院到熟练护理机构的比例明显高于基线期（p = 0.016）；未发现其他有意义的比较。基线期每位患者每天的平均（±SD）抗菌药物费用为 75.37 ± 11.85 美元，干预期为 64.13 ± 13.78 美元（p = 0.022）。这一差异代表在两年的干预期间节省了 261630 美元的成本。
在实施 ASP 后两年期间，观察到抗菌药物成本降低。该 ASP 将药学学生作为计划的不可或缺的成员纳入其中。
