Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Department of Pathology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Eur J Surg Oncol. 2014 Mar;40(3):255-9. doi: 10.1016/j.ejso.2013.12.018. Epub 2014 Jan 2.
This research aims to specify the prognostic value of P-cadherin on recurrence and progression in non-muscle-invasive bladder cancers (NMIBC).
A total of 110 NMIBC cases were collected and P-cadherin protein was assessed by immunohistochemical test in these samples. Correlations between P-cadherin expression and clinicopathologic features were analyzed. For recurrence-free and progression-free survival, Kaplan-Meier log-rank test was used. Then Cox univariate and multivariate analyses were further performed.
P-cadherin high expression correlated with tumor progression (P = 0.031). Kaplan-Meier results showed that patients with high P-cadherin expression had worse progression-free survival (P = 0.034) but not recurrence-free survival (P = 0.133) than low-expression patients. Cox regression results showed P-cadherin expression was an independent predictor for progression (P = 0.042) but not recurrence (P = 0.139) in NMIBC.
Our results demonstrated that P-cadherin expression correlated with tumor progression and could be taken as an independent predictor for progression in NMIBC.
本研究旨在明确 P-钙黏蛋白（P-cadherin）在非肌层浸润性膀胱癌（NMIBC）复发和进展中的预后价值。
收集了 110 例 NMIBC 病例，并通过免疫组织化学试验对这些样本中的 P-cadherin 蛋白进行评估。分析 P-cadherin 表达与临床病理特征之间的相关性。采用 Kaplan-Meier 对数秩检验分析无复发生存期和无进展生存期，然后进行 Cox 单因素和多因素分析。
P-cadherin 高表达与肿瘤进展相关（P=0.031）。Kaplan-Meier 结果显示，P-cadherin 高表达患者的无进展生存期（P=0.034）较低表达患者差，但无复发生存期（P=0.133）无差异。Cox 回归结果显示，P-cadherin 表达是 NMIBC 进展的独立预测因子（P=0.042），但不是复发的独立预测因子（P=0.139）。
我们的结果表明，P-cadherin 表达与肿瘤进展相关，可作为 NMIBC 进展的独立预测因子。
