Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
J Surg Oncol. 2013 Jun;107(7):758-61. doi: 10.1002/jso.23317. Epub 2013 Apr 23.
RING box protein-1 (RBX1) is a key subunit of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F-box protein complex. Altered expression RBX1 is shown to associate with tumorigenesis and tumor progression. This study detected RBX1 expression for association with clinical significance (such as clinicopathological data and survival of the patients) in non-muscle-invasive bladder transitional cell carcinoma (NMIBC).
A total of 70 primary NMIBC tissue specimens and 24 normal tissue specimens were recruited and analyzed immunohistochemically for expression of RBX1 protein and associated with clinicopathological data and survival of the patients.
RBX1 was highly expressed in NMIBC, but was lowly expressed in the normal tissue. RBX1 expression was associated with high tumor grade and advanced clinical stage (P < 0.01 and P < 0.05, respectively). Moreover, patients with high RBX1 expression had shorter recurrence-free survival and progression-free survival rates (P < 0.001 and P < 0.01, respectively). Multivariate analysis demonstrated that RBX1 expression is an independent prognostic factor for tumor recurrence and progression of NMIBC (P < 0.05).
Overexpression of RBX1 protein contributes to tumor progression and poor prognosis of NMIBC.
环指蛋白 1（RBX1）是泛素 E3 连接酶 Skp1/Cullin1/Rbx1/F-box 蛋白复合物的关键亚基。RBX1 表达的改变与肿瘤发生和肿瘤进展有关。本研究检测了 RBX1 在非肌层浸润性膀胱癌（NMIBC）中的表达与临床意义（如临床病理数据和患者生存）的关系。
共招募了 70 例原发性 NMIBC 组织标本和 24 例正常组织标本，通过免疫组织化学法检测 RBX1 蛋白的表达，并与临床病理数据和患者生存情况进行相关性分析。
RBX1 在 NMIBC 中高表达，而在正常组织中低表达。RBX1 的表达与高肿瘤分级和晚期临床分期相关（P<0.01 和 P<0.05）。此外，高 RBX1 表达的患者无复发生存率和无进展生存率较低（P<0.001 和 P<0.01）。多因素分析表明，RBX1 表达是 NMIBC 肿瘤复发和进展的独立预后因素（P<0.05）。
RBX1 蛋白的过表达促进了 NMIBC 的肿瘤进展和不良预后。
