Majak P, Lunde I G, Hasic A K, Husebye T, Christensen G, Tønnessen T, Bjørnstad J L
Department of Cardiothoracic Surgery, Oslo University Hospital, Ullevål, Oslo, Norway -
J Cardiovasc Surg (Torino). 2015 Jun;56(3):483-92. Epub 2014 Jan 16.
Visfatin may play a part in reverse left ventricular remodelling. Using a mouse model of reversible left ventricle pressure overload, we examined if visfatin was altered in the myocardium. Furthermore, we addressed this issue in patients with aortic stenosis (AS) and examined whether visfatin levels are related to reverse remodelling following aortic valve replacement (AVR).
Myocardial visfatin was analysed after aortic banding (AB) and debanding (DB) in mice and compared to sham operated animals. Myocardial visfatin was measured in biopsies from patients undergoing AVR and compared to controls. Serum visfatin was measured before and after AVR in patients with AS and correlated with echocardiographic measurments of cardiac morphology and function.
Four weeks after AB, myocardial visfatin protein was reduced by 50% compared to sham. Three days after DB, myocardial protein levels increased significantly. Myocardial visfatin and serum visfatin levels were reduced by 23% and 64%, respectively, in patients with AS compared to controls. Twelve months after AVR, serum visfatin levels increased compared to preoperative values and correlated negatively with degree of left ventricular hypertrophy.
Myocardial visfatin and serum visfatin levels are reduced by cardiac pressure overload. Visfatin levels increase after correction of pressure overload and may play a part in postoperative reverse remodelling.
内脂素可能参与左心室逆向重构。我们利用可逆性左心室压力超负荷小鼠模型，研究心肌内脂素是否发生改变。此外，我们在主动脉瓣狭窄（AS）患者中探讨了这一问题，并研究内脂素水平与主动脉瓣置换术（AVR）后逆向重构是否相关。
对小鼠进行主动脉缩窄（AB）和解除缩窄（DB）后，分析心肌内脂素，并与假手术动物进行比较。测量接受AVR患者活检组织中的心肌内脂素，并与对照组进行比较。测量AS患者AVR前后的血清内脂素，并将其与心脏形态和功能的超声心动图测量值相关联。
AB后四周，与假手术组相比，心肌内脂素蛋白减少50%。DB后三天，心肌蛋白水平显著升高。与对照组相比，AS患者的心肌内脂素和血清内脂素水平分别降低了23%和64%。AVR后十二个月，血清内脂素水平较术前升高，且与左心室肥厚程度呈负相关。
心脏压力超负荷可降低心肌内脂素和血清内脂素水平。压力超负荷纠正后，内脂素水平升高，可能参与术后逆向重构。
