• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

前边缘区和下边缘区多巴胺在条件性线索和位置偏好中的相反作用。

Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference.

作者信息

Hayen Anja, Meese-Tamuri Saira, Gates Amy, Ito Rutsuko

机构信息

Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK.

出版信息

Psychopharmacology (Berl). 2014 Jun;231(12):2483-92. doi: 10.1007/s00213-013-3414-0. Epub 2014 Jan 16.

DOI:10.1007/s00213-013-3414-0
PMID:24429871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4039995/
Abstract

RATIONALE

Increasing evidence points to the prelimbic (PL) and infralimbic (IL) cortices of the medial prefrontal cortex (mPFC) and their dopaminergic innervations subserving opposing roles in the regulation of instrumental behavior. However, it is at present unclear if they hold similar roles in the regulation of Pavlovian learning.

OBJECTIVE

The present study investigated the role of the dopaminergic innervations of the PL and IL in the modulation of Pavlovian appetitive cue and place conditioning, previously shown to be dependent on the basolateral amygdala and hippocampus, respectively.

METHODS

Rats received preconditioning microinfusions of D-amphetamine, cis-flupenthixol, or vehicle solution directly into the PL or IL and were trained to simultaneously acquire conditioned cue and place preference in a radial maze.

RESULTS

Preconditioning blockade of dopamine neurotransmission in the PL and amphetamine microinfusions in the IL had the same effect of attenuating place conditioning. In contrast, place conditioning remained intact following preconditioning amphetamine microinfusions in the PL and dopamine receptor blockade in the IL. Instead, conditioned cue preference was attenuated following IL dopamine receptor blockade.

CONCLUSION

These data indicate that PL dopaminergic mechanisms are critical for the acquisition of appetitive place learning, while IL dopamine may oppose the influence of PL dopamine upon hippocampal-dependent learning. Furthermore, they implicate a functional reciprocity between mPFC and associated subregions of the nucleus accumbens in the regulation of limbic information processing.

摘要

理论依据

越来越多的证据表明，内侧前额叶皮质（mPFC）的前边缘（PL）和下边缘（IL）皮质及其多巴胺能神经支配在工具性行为调节中发挥着相反的作用。然而，目前尚不清楚它们在巴甫洛夫学习调节中是否具有类似作用。

目的

本研究调查了PL和IL的多巴胺能神经支配在巴甫洛夫式食欲线索调节和位置条件反射中的作用，先前研究表明这分别依赖于基底外侧杏仁核和海马体。

方法

给大鼠在PL或IL中预先注入D-苯丙胺、顺式氟奋乃静或溶剂，然后训练它们在放射状迷宫中同时获得条件线索偏好和位置偏好。

结果

预先阻断PL中的多巴胺神经传递以及在IL中注入苯丙胺，对减弱位置条件反射具有相同的效果。相反，在PL中预先注入苯丙胺以及阻断IL中的多巴胺受体后，位置条件反射保持完好。相反，阻断IL中的多巴胺受体后，条件线索偏好减弱。

结论

这些数据表明，PL多巴胺能机制对获得食欲性位置学习至关重要，而IL多巴胺可能会对抗PL多巴胺对海马体依赖性学习的影响。此外，它们表明在边缘信息处理调节中，mPFC与伏隔核相关亚区域之间存在功能互惠关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/501a5ebd8c8a/213_2013_3414_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/ae0e7f8278d6/213_2013_3414_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/ed6af007f712/213_2013_3414_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/35b4644a3e30/213_2013_3414_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/c24713b43fb2/213_2013_3414_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/501a5ebd8c8a/213_2013_3414_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/ae0e7f8278d6/213_2013_3414_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/ed6af007f712/213_2013_3414_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/35b4644a3e30/213_2013_3414_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/c24713b43fb2/213_2013_3414_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bf8/4039995/501a5ebd8c8a/213_2013_3414_Fig5_HTML.jpg

相似文献

1
Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference.前边缘区和下边缘区多巴胺在条件性线索和位置偏好中的相反作用。
Psychopharmacology (Berl). 2014 Jun;231(12):2483-92. doi: 10.1007/s00213-013-3414-0. Epub 2014 Jan 16.
2
Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing.伏隔核核心和壳部多巴胺在调节边缘信息处理中的拮抗作用。
J Neurosci. 2011 Apr 20;31(16):6001-7. doi: 10.1523/JNEUROSCI.6588-10.2011.
3
Norepinephrine in prelimbic cortex delays extinction of amphetamine-induced conditioned place preference.前边缘皮层中的去甲肾上腺素会延迟苯丙胺诱导的条件性位置偏好的消退。
Psychopharmacology (Berl). 2016 Mar;233(6):973-82. doi: 10.1007/s00213-015-4177-6. Epub 2015 Dec 12.
4
Amphetamine exposure selectively enhances hippocampus-dependent spatial learning and attenuates amygdala-dependent cue learning.安非他命暴露会选择性地增强海马体依赖的空间学习，减弱杏仁核依赖的线索学习。
Neuropsychopharmacology. 2010 Jun;35(7):1440-52. doi: 10.1038/npp.2010.14. Epub 2010 Mar 3.
5
Excitotoxic lesions of the infralimbic, but not prelimbic cortex facilitate reversal of appetitive discriminative context conditioning: the role of the infralimbic cortex in context generalization.边缘下皮质而非边缘前皮质的兴奋性毒性损伤促进了食欲辨别性情境条件反射的逆转：边缘下皮质在情境泛化中的作用。
Front Behav Neurosci. 2014 Feb 28;8:63. doi: 10.3389/fnbeh.2014.00063. eCollection 2014.
6
Interplay of prefrontal cortex and amygdala during extinction of drug seeking.前额皮质和杏仁核在药物寻求消退过程中的相互作用。
Brain Struct Funct. 2018 Apr;223(3):1071-1089. doi: 10.1007/s00429-017-1533-9. Epub 2017 Oct 28.
7
Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure.在一种新型Y迷宫实验中，基于路径整合，海马体和基底外侧杏仁核的选择性兴奋性毒性损伤对食欲线索和位置条件作用具有可分离的影响。
Eur J Neurosci. 2006 Jun;23(11):3071-80. doi: 10.1111/j.1460-9568.2006.04883.x.
8
The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex.小脑在药物线索关联记忆中的作用：与内侧前额叶皮质的功能相互作用。
Eur J Neurosci. 2019 Aug;50(3):2613-2622. doi: 10.1111/ejn.14187. Epub 2018 Oct 24.
9
Abstinence from Cocaine-Induced Conditioned Place Preference Produces Discrete Changes in Glutamatergic Synapses onto Deep Layer 5/6 Neurons from Prelimbic and Infralimbic Cortices.可卡因诱导的条件性位置偏好戒除会导致边缘前皮质和边缘下皮质深部 5/6 层神经元的谷氨酸能突触发生离散变化。
eNeuro. 2017 Dec 13;4(6). doi: 10.1523/ENEURO.0308-17.2017. eCollection 2017 Nov-Dec.
10
Medial prefrontal cortex inactivation attenuates the diurnal rhythm in amphetamine reward.内侧前额叶皮质失活减弱了苯丙胺奖赏的昼夜节律。
Neuroscience. 2014 Jan 31;258:204-10. doi: 10.1016/j.neuroscience.2013.11.013. Epub 2013 Nov 15.

引用本文的文献

1
Sex-Specific and Traumatic Brain Injury Effects on Dopamine Receptor Expression in the Hippocampus.性别特异性和创伤性脑损伤对海马多巴胺受体表达的影响。
Int J Mol Sci. 2023 Nov 8;24(22):16084. doi: 10.3390/ijms242216084.
2
Chronic Alcohol Drinking Drives Sex-Specific Differences in Affective Behavior and Medial Prefrontal Cortex Activity in CRF1:Cre:tdTomato Transgenic Rats.慢性酒精摄入导致 CRF1:Cre:tdTomato 转基因大鼠在情感行为和内侧前额叶皮质活动方面出现性别特异性差异。
eNeuro. 2023 Jul 13;10(7). doi: 10.1523/ENEURO.0055-23.2023. Print 2023 Jul.
3
The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.

本文引用的文献

1
The role of medial prefrontal cortex in memory and decision making.内侧前额叶皮层在记忆和决策中的作用。
Neuron. 2012 Dec 20;76(6):1057-70. doi: 10.1016/j.neuron.2012.12.002.
2
Prefrontal cortex modulates desire and dread generated by nucleus accumbens glutamate disruption.前额皮质调节伏隔核谷氨酸破坏产生的欲望和恐惧。
Biol Psychiatry. 2013 Feb 15;73(4):360-70. doi: 10.1016/j.biopsych.2012.08.009. Epub 2012 Sep 13.
3
Role of projections from ventral medial prefrontal cortex to nucleus accumbens shell in context-induced reinstatement of heroin seeking.
在多变的需求下，调节适应行为的啮齿动物内侧前额叶皮层和相关回路。
Neurosci Biobehav Rev. 2022 Apr;135:104569. doi: 10.1016/j.neubiorev.2022.104569. Epub 2022 Feb 4.
4
Optogenetic manipulation of the prelimbic cortex during fear memory reconsolidation alters fear extinction in a preclinical model of comorbid PTSD/AUD.在共病 PTSD/AUD 的临床前模型中，在恐惧记忆再巩固期间对前额皮质进行光遗传操作会改变恐惧的消除。
Psychopharmacology (Berl). 2021 Nov;238(11):3193-3206. doi: 10.1007/s00213-021-05935-3. Epub 2021 Aug 4.
5
Transgenerational evidence of increases in dopamine D2 receptor sensitivity in rodents: Impact on sensorimotor gating, the behavioral response to nicotine and BDNF.跨代证据表明啮齿动物多巴胺 D2 受体敏感性增加：对感觉运动门控、尼古丁和 BDNF 的行为反应的影响。
J Psychopharmacol. 2021 Oct;35(10):1188-1203. doi: 10.1177/02698811211033927. Epub 2021 Jul 22.
6
A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence.前额皮质在可卡因戒断前后冲动行为中的性别依赖性作用。
Neuropsychopharmacology. 2021 Aug;46(9):1565-1573. doi: 10.1038/s41386-021-01024-3. Epub 2021 May 10.
7
Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations.安非他命诱导的 conditioned place preference 在老鼠体内被 ayahuasca 阻断：行为和大脑 Fos 表达评估。
Psychopharmacology (Berl). 2020 Nov;237(11):3269-3281. doi: 10.1007/s00213-020-05609-6. Epub 2020 Jul 16.
8
Increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-A (hypocretin-1).鼻腔内给予食欲素 A（下丘脑分泌素-1）后前额叶皮层乙酰胆碱和谷氨酸的外排增加。
J Neurochem. 2018 May;145(3):232-244. doi: 10.1111/jnc.14279. Epub 2018 Jan 12.
9
Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation.中脑边缘单胺系统与甲基苯丙胺敏化和动机的相关性。
Front Syst Neurosci. 2014 May 7;8:70. doi: 10.3389/fnsys.2014.00070. eCollection 2014.
10
Excitotoxic lesions of the infralimbic, but not prelimbic cortex facilitate reversal of appetitive discriminative context conditioning: the role of the infralimbic cortex in context generalization.边缘下皮质而非边缘前皮质的兴奋性毒性损伤促进了食欲辨别性情境条件反射的逆转：边缘下皮质在情境泛化中的作用。
Front Behav Neurosci. 2014 Feb 28;8:63. doi: 10.3389/fnbeh.2014.00063. eCollection 2014.
伏隔核壳部腹内侧前额叶投射在情境诱发海洛因觅药行为中的作用。
J Neurosci. 2012 Apr 4;32(14):4982-91. doi: 10.1523/JNEUROSCI.0005-12.2012.
4
Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell.可卡因觅药行为中的神经回路竞争：伏隔核壳和边缘下皮质的作用。
Eur J Neurosci. 2012 Feb;35(4):614-22. doi: 10.1111/j.1460-9568.2012.07991.x. Epub 2012 Feb 9.
5
Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing.伏隔核核心和壳部多巴胺在调节边缘信息处理中的拮抗作用。
J Neurosci. 2011 Apr 20;31(16):6001-7. doi: 10.1523/JNEUROSCI.6588-10.2011.
6
Amphetamine exposure selectively enhances hippocampus-dependent spatial learning and attenuates amygdala-dependent cue learning.安非他命暴露会选择性地增强海马体依赖的空间学习，减弱杏仁核依赖的线索学习。
Neuropsychopharmacology. 2010 Jun;35(7):1440-52. doi: 10.1038/npp.2010.14. Epub 2010 Mar 3.
7
Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking.前额皮质和伏隔核在重新引发甲基苯丙胺觅药行为中的作用。
Eur J Neurosci. 2010 Mar;31(5):903-9. doi: 10.1111/j.1460-9568.2010.07134.x. Epub 2010 Feb 17.
8
Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking.伏隔核核心和壳在情境和线索诱导的酒精觅药中的可分离作用。
Neuropsychopharmacology. 2010 Feb;35(3):783-91. doi: 10.1038/npp.2009.187. Epub 2009 Nov 18.
9
A role for medial prefrontal dopaminergic innervation in instrumental conditioning.内侧前额叶多巴胺能神经支配在工具性条件反射中的作用。
J Neurosci. 2009 May 20;29(20):6599-606. doi: 10.1523/JNEUROSCI.1234-09.2009.
10
Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration.可卡因在偶然给药和非偶然给药后对谷氨酸和多巴胺转运体的差异性调节。
Neuropharmacology. 2008 Oct;55(5):771-9. doi: 10.1016/j.neuropharm.2008.06.042. Epub 2008 Jun 27.