失眠的管理：当前及未来使用的失眠症概述及药物治疗策略
Managing insomnia: an overview of insomnia and pharmacologic treatment strategies in use and on the horizon.
作者信息
Schwartz Thomas L, Goradia Viral
机构信息
SUNY Upstate Medical University, Psychiatry Department, Syracuse, NY 13210, USA.
出版信息
Drugs Context. 2013 Oct 4;2013:212257. doi: 10.7573/dic.212257.
Abstract
This review explores basic sleep physiology, the mechanism of action for each class of hypnotic agents, their clinical application based on pharmacodynamic and pharmacokinetic factors, and potential pharmacologic sleep-inducing mechanisms of future hypnotics. The paper challenges the reader to understand the neuroscientific basis of insomnia and use this knowledge to guide prescription of hypnotic agents. Currently indicated hypnotic agents are discussed with regard to their mechanism of drug action and clinical application. A broader discussion is developed throughout this paper regarding other non-indicated agents that may improve sleep and describing newer pharmacological treatments that may become available in the future for use in sleep disorders and their comorbid conditions.
摘要
本综述探讨了基本睡眠生理学、各类催眠药物的作用机制、基于药效学和药代动力学因素的临床应用，以及未来催眠药物潜在的诱导睡眠药理机制。本文促使读者理解失眠的神经科学基础，并利用这些知识指导催眠药物的处方。文中讨论了目前已获适应证的催眠药物的药物作用机制和临床应用。本文还更广泛地讨论了其他可能改善睡眠的未获适应证药物，并描述了未来可能用于治疗睡眠障碍及其合并症的新型药物治疗方法。
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