蒙古蒲公英中的一种新肌醇三酯。

A new inositol triester from Taraxacum mongolicum.

机构信息

a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.

出版信息

Nat Prod Res. 2014;28(7):420-3. doi: 10.1080/14786419.2013.867443. Epub 2014 Jan 16.

DOI:10.1080/14786419.2013.867443

PMID:24432736

Abstract

One new inositol triester, 4,5,6-tri-O-p-hydroxyphenylacetyl-chiro-inositol (1), was isolated from the ethanolic extract of Taraxacum mongolicum, along with two known compounds, 11β,13-dihydrotaraxinic acid (2) and taraxinic acid β-d-glucopyranosyl ester (3). The isolates were tested for their anti-hepatitis B virus (HBV) activities; 11β,13-dihydrotaraxinic acid (2) exhibited an IC50 value of 0.91 mM inhibiting the secretion of the HBV surface antigen and an IC50 value of 0.34 mM inhibiting the secretion of the HBV e antigen using HBV transfected Hep G2.2.15 cell line.

摘要

从蒙古蒲公英的乙醇提取物中分离得到一个新的肌醇三酯，4,5,6-三-O-对羟苯乙酰手性肌醇（1），以及两种已知化合物，11β,13-二氢蒲公英酸（2）和蒲公英酸β-D-吡喃葡萄糖苷酯（3）。对分离物进行抗乙型肝炎病毒（HBV）活性测试；11β,13-二氢蒲公英酸（2）在 HBV 转染 Hep G2.2.15 细胞系中抑制 HBV 表面抗原分泌的 IC50 值为 0.91 mM，抑制 HBV e 抗原分泌的 IC50 值为 0.34 mM。