Psychology Department, Goldsmiths, University of London, New Cross, London SE14 6NW, UK.
BMC Med. 2014 Jan 16;12:7. doi: 10.1186/1741-7015-12-7.
Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life stress and Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has received much attention. The aim of the present work was to review and conduct a meta-analysis on the results from published studies examining this interaction.
A literature search was conducted using PsychINFO and PubMed databases until 22 November 2013. A total of 22 studies with a pooled total of 14,233 participants met the inclusion criteria, the results of which were combined and a meta-analysis performed using the Liptak-Stouffer z-score method.
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). When the studies were stratified by type of environmental stressor, the evidence was stronger for an interaction with stressful life events (P = 0.01) and weaker for interaction of BDNF Val66Met with childhood adversity (P = 0.051).
The interaction between BDNF and life stress in depression is stronger for stressful life events rather than childhood adversity. Methodological limitations of existing studies include poor measurement of life stress.
重度抑郁症是一种具有复杂起源的致残性精神疾病。生活压力（童年逆境和近期压力事件）是抑郁症的一个强有力的风险因素。生活压力与脑源性神经营养因子（BDNF）基因 Val66Met 多态性之间的关系受到了广泛关注。本研究旨在回顾和进行荟萃分析，以评估发表的研究结果。
使用 PsychINFO 和 PubMed 数据库进行文献检索，检索截至 2013 年 11 月 22 日。共有 22 项研究符合纳入标准，共纳入 14233 名参与者，对这些研究的结果进行了合并，并使用 Liptak-Stouffer z 分数法进行荟萃分析。
结果表明，BDNF Val66Met 多态性的 Met 等位基因显著调节生活压力与抑郁之间的关系（P=0.03）。当按环境应激源的类型对研究进行分层时，BDNF 与生活事件之间的相互作用证据更强（P=0.01），而 BDNF 与童年逆境之间的相互作用较弱（P=0.051）。
BDNF 与生活压力在抑郁症中的相互作用在生活事件方面比在童年逆境方面更强。现有研究的方法学局限性包括生活压力测量不佳。
