Hong Soyoung, Choi Won-Jun, Kwon Ho-Jang, Cho Yoon Hee, Yum Hye Yung, Son Dong Koog
Department of Environmental Health Research, Seoul Medical Center, Seoul, Republic of Korea.
Allergy Asthma Proc. 2014 Jan-Feb;35(1):66-70. doi: 10.2500/aap.2014.35.3716.
The effect of breast-feeding on the risk of developing atopic disease remains controversial. This study is an investigation of the effect of breast-feeding on current atopic dermatitis (AD) among Korean children. This cross-sectional study of children's histories of current AD and environmental factors was completed by the subjects' parents. The subjects included 10,383 children aged 0-13 years in Seoul, Korea, in 2008. The diagnostic criteria of the International Study of Asthma and Allergies in Childhood were applied in this study. Adjustments were performed for age, gender, maternal education, smoking in the household, relocation to a new house within 1 year of birth, and parental history of atopic disease. After adjustment for confounders, age and duration of maternal education were found to be inversely associated with the prevalence of AD. Among subjects aged ≤5 years, the prevalence of AD was positively associated with the duration of breast-feeding (p < 0.001). However, there was no significant association between AD and breast-feeding among children >5 years of age. Regardless of parental history of atopic diseases, breast-feeding >12 months was a significant risk factor for AD. The effect of breast-feeding differed by age group. Prolonged breast-feeding increased the risk of AD in children <5 years of age, regardless of parental history of atopic diseases.
母乳喂养对患特应性疾病风险的影响仍存在争议。本研究旨在调查母乳喂养对韩国儿童目前患特应性皮炎（AD）的影响。这项关于儿童目前AD病史和环境因素的横断面研究由受试者的父母完成。研究对象包括2008年韩国首尔的10383名0至13岁儿童。本研究采用了儿童哮喘和过敏国际研究的诊断标准。对年龄、性别、母亲教育程度、家庭吸烟情况、出生后1年内搬入新房以及父母特应性疾病史进行了调整。在对混杂因素进行调整后，发现年龄和母亲受教育时间与AD患病率呈负相关。在年龄≤5岁的受试者中，AD患病率与母乳喂养时间呈正相关（p<0.001）。然而，在5岁以上儿童中，AD与母乳喂养之间没有显著关联。无论父母是否有特应性疾病史，母乳喂养超过12个月都是AD的一个重要危险因素。母乳喂养的影响因年龄组而异。无论父母是否有特应性疾病史，延长母乳喂养都会增加5岁以下儿童患AD的风险。
