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特应性皮炎:自然病史、诊断与治疗

Atopic dermatitis: natural history, diagnosis, and treatment.

作者信息

Thomsen Simon Francis

机构信息

Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.

出版信息

ISRN Allergy. 2014 Apr 2;2014:354250. doi: 10.1155/2014/354250. eCollection 2014.

DOI:10.1155/2014/354250
PMID:25006501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4004110/
Abstract

Atopic dermatitis is an inflammatory skin disease with early onset and with a lifetime prevalence of approximately 20%. The aetiology of atopic dermatitis is unknown, but the recent discovery of filaggrin mutations holds promise that the progression of atopic dermatitis to asthma in later childhood may be halted. Atopic dermatitis is not always easily manageable and every physician should be familiar with the fundamental aspects of treatment. This paper gives an overview of the natural history, clinical features, and treatment of atopic dermatitis.

摘要

特应性皮炎是一种早发性炎症性皮肤病,终生患病率约为20%。特应性皮炎的病因尚不清楚,但最近发现的丝聚合蛋白突变有望在儿童后期阻止特应性皮炎发展为哮喘。特应性皮炎并非总是易于控制,每位医生都应熟悉其基本治疗方法。本文概述了特应性皮炎的自然病史、临床特征和治疗方法。

相似文献

1
Atopic dermatitis: natural history, diagnosis, and treatment.特应性皮炎:自然病史、诊断与治疗
ISRN Allergy. 2014 Apr 2;2014:354250. doi: 10.1155/2014/354250. eCollection 2014.
2
Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma.丝聚合蛋白突变会使人易患特应性皮炎,但不会使人易患哮喘。
J Allergy Clin Immunol. 2007 Dec;120(6):1332-7. doi: 10.1016/j.jaci.2007.09.037.
3
Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.儿童特应性皮炎的表型取决于发病时间和病程进展情况。
JAMA Pediatr. 2017 Jul 1;171(7):655-662. doi: 10.1001/jamapediatrics.2017.0556.
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The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma.特应性进程:从特应性皮炎发展为变应性鼻炎和哮喘
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Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities.特应性皮炎在 TOACS 队列中从青少年到成年:患病率、持续性和共病。
Allergy. 2015 Jul;70(7):836-45. doi: 10.1111/all.12619. Epub 2015 Apr 16.
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The ins and outs of an 'outside-in' view of allergies: atopic dermatitis and allergy prevention.过敏的“由外而内”观点面面观:特应性皮炎与过敏预防。
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Hand eczema, atopic dermatitis and filaggrin mutations in adult Danes: a registry-based study assessing risk of disability pension.丹麦成年人手部湿疹、特应性皮炎和丝聚蛋白突变:基于登记的研究评估残疾抚恤金风险。
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8
The role of filaggrin loss-of-function mutations in atopic dermatitis.丝聚合蛋白功能丧失突变在特应性皮炎中的作用。
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Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible.纯合子 2282del4 和 R501X 缺失突变的人并非一定会发展为皮炎,且完全长期缓解是可能的。
J Eur Acad Dermatol Venereol. 2012 Mar;26(3):386-9. doi: 10.1111/j.1468-3083.2011.04073.x. Epub 2011 Apr 19.
10
Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood.丝聚合蛋白基因型与儿童期独立于特应性皮炎的皮肤疾病
Pediatr Allergy Immunol. 2016 Mar;27(2):162-8. doi: 10.1111/pai.12511. Epub 2015 Dec 21.

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Oral administration of GKK1 ameliorates atopic dermatitis in a mouse model.口服GKK1可改善小鼠模型中的特应性皮炎。
Front Microbiol. 2025 Jun 3;16:1566594. doi: 10.3389/fmicb.2025.1566594. eCollection 2025.
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The APOLO Study: A Cross-Sectional Analysis of Disease Characteristics and Patient Burden in Moderate-to-Severe Atopic Dermatitis in Portugal.阿波洛研究:葡萄牙中重度特应性皮炎疾病特征与患者负担的横断面分析
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本文引用的文献

1
Effect of prolonged breast-feeding on risk of atopic dermatitis in early childhood.延长母乳喂养对幼儿期患特应性皮炎风险的影响。
Allergy Asthma Proc. 2014 Jan-Feb;35(1):66-70. doi: 10.2500/aap.2014.35.3716.
2
Association between parental socioeconomic position and prevalence of asthma, atopic eczema and hay fever in children.父母社会经济地位与儿童哮喘、特应性皮炎和花粉热患病率的关系。
Scand J Public Health. 2014 Mar;42(2):120-7. doi: 10.1177/1403494813505727. Epub 2013 Oct 2.
3
Immunology of atopic eczema: overcoming the Th1/Th2 paradigm.特应性皮炎的免疫学:超越 Th1/Th2 范式。
Allergy. 2013 Aug;68(8):974-82. doi: 10.1111/all.12184. Epub 2013 Jul 29.
4
Maternal farm exposure/ingestion of unpasteurized cow's milk and allergic disease.母亲在农场接触/摄入未经巴氏消毒的牛奶与过敏疾病。
Curr Opin Gastroenterol. 2012 Nov;28(6):570-6. doi: 10.1097/MOG.0b013e32835955d3.
5
Guidelines for treatment of atopic eczema (atopic dermatitis) part I.特应性皮炎(特应性湿疹)治疗指南 第一部分。
J Eur Acad Dermatol Venereol. 2012 Aug;26(8):1045-60. doi: 10.1111/j.1468-3083.2012.04635.x.
6
Skin barrier disruption: a requirement for allergen sensitization?皮肤屏障破坏:变应原致敏的必要条件?
J Invest Dermatol. 2012 Mar;132(3 Pt 2):949-63. doi: 10.1038/jid.2011.435. Epub 2012 Jan 5.
7
Filaggrin mutations associated with skin and allergic diseases.与皮肤和过敏性疾病相关的丝聚合蛋白突变。
N Engl J Med. 2011 Oct 6;365(14):1315-27. doi: 10.1056/NEJMra1011040.
8
From atopic dermatitis to asthma: the atopic march.从特应性皮炎到哮喘:特应性进行曲。
Ann Allergy Asthma Immunol. 2010 Aug;105(2):99-106; quiz 107-9, 117. doi: 10.1016/j.anai.2009.10.002. Epub 2010 Jan 22.
9
Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review.干预措施减少金黄色葡萄球菌在特应性皮炎管理:一个更新的 Cochrane 综述。
Br J Dermatol. 2010 Jul;163(1):12-26. doi: 10.1111/j.1365-2133.2010.09743.x. Epub 2010 Mar 5.
10
Atopic dermatitis: a review of topical treatment options.特应性皮炎:局部治疗选择的综述。
Curr Med Res Opin. 2010 Mar;26(3):633-40. doi: 10.1185/03007990903512156.