Liang Qing-Feng, Sun Xu-Guang, Labbe Antoine
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100005, China.
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Zhonghua Yan Ke Za Zhi. 2013 Oct;49(10):951-5.
Infectious keratitis remains a severe ocular condition that can lead to irreversible complications and even blindness. An early diagnosis of an infective microorganism leading to effective treatment may improve the outcome of infectious keratitis.However, the accurate and rapid identification of the infectious agent remains a challenge for the ophthalmologist.In vivo confocal microscopy (IVCM) is a noninvasive imaging technique that provides high-resolution images of ocular surface structures at a cellular level and infectious keratitis represents one of its most important clinical uses. The value of IVCM has been demonstrated in the diagnosis of acanthamoeba and filamentous fungal keratitis. The follow-up of such corneal infections may also be improved by this noninvasive imaging technique.However, the current resolution of IVCM limits its use in cases of bacterial and viral keratitis.
感染性角膜炎仍然是一种严重的眼部疾病,可导致不可逆的并发症甚至失明。早期诊断导致感染的微生物并进行有效治疗,可能会改善感染性角膜炎的治疗效果。然而,准确、快速地识别感染病原体对眼科医生来说仍是一项挑战。共聚焦显微镜活体成像(IVCM)是一种非侵入性成像技术,可在细胞水平提供眼表结构的高分辨率图像,感染性角膜炎是其最重要的临床应用之一。IVCM在棘阿米巴角膜炎和丝状真菌性角膜炎的诊断中已显示出价值。这种非侵入性成像技术也可能改善此类角膜感染的随访情况。然而,IVCM目前的分辨率限制了其在细菌性和病毒性角膜炎病例中的应用。