[散发性肾血管母细胞瘤的临床病理特征]

[Clinicopathologic characteristics of sporadic renal hemangioblastoma].

作者信息

Guo Jing, Li Liang, Zhao Li-hua, Li Yan, Wang Lin-sheng, Xiao Lin, Zhang Ren-ya

机构信息

Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272029, China.

Department of Pathology,Jining First People's Hospital, Jining 272011, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2013 Oct;42(10):679-82.

PMID:24433731

Abstract

OBJECTIVE

To investigate the clinicopathological characteristics of sporadic renal hemangioblastoma.

METHODS

Two cases of sporadic renal hemangioblastoma were studied by histological and immunohistochemical staining, along with review of the literature.

RESULTS

Both cases were presented with a renal mass during annual physical examination with an age of 40 and 45 years, respectively. The lesions located in the middle portion of the kidney with a sharp tumor border. Histopathologically, the tumors were characterized by two major components: capillary and stromal cells. Immunohistochemically, the stromal cells were positive for vimentin, NSE, S-100 protein and inhibin-α, and negative for CK, HMB45, Melan A, EMA, CD56 and syn. Both tumors showed a very low level of Ki-67 labeling. The endothelial cells were positive for CD34.

CONCLUSION

Sporadic renal hemangioblastoma is a rare benign neoplasm, the diagnosis of which is based on the characteristic follicular architecture and an exclusion of other carcinomas of the kidney.

摘要

目的

探讨散发性肾血管母细胞瘤的临床病理特征。

方法

对2例散发性肾血管母细胞瘤进行组织学和免疫组化染色研究，并复习相关文献。

结果

2例患者均在年度体检时发现肾脏肿块，年龄分别为40岁和45岁。病变位于肾脏中部，肿瘤边界清晰。组织病理学上，肿瘤主要由两种成分组成：毛细血管和间质细胞。免疫组化结果显示，间质细胞波形蛋白、神经元特异性烯醇化酶、S-100蛋白和抑制素-α呈阳性，细胞角蛋白、HMB45、Melan A、上皮膜抗原、CD56和突触素呈阴性。2例肿瘤的Ki-67标记指数均很低。内皮细胞CD34呈阳性。