首次报告在叶酸和甘氨酸存在下伏安法测定甲基多巴。
First report for voltammetric determination of methyldopa in the presence of folic acid and glycine.
机构信息
Department of Chemistry, Shahid Bahonar University of Kerman, P.O. Box 76175-133, Kerman, Iran; Young Researchers Society, Shahid Bahonar University of Kerman, P.O. Box 76175-133, Kerman, Iran.
Department of Chemistry, Shahid Bahonar University of Kerman, P.O. Box 76175-133, Kerman, Iran.
出版信息
Mater Sci Eng C Mater Biol Appl. 2014 Mar 1;36:168-72. doi: 10.1016/j.msec.2013.12.013. Epub 2013 Dec 14.
In this study, a carbon paste electrode modified with TiO2 nanoparticles and ferrocene monocarboxylic acid (FM) was used to prepare a novel electrochemical sensor. The objective of this novel electrode modification was to seek new electrochemical performances for the detection of methyldopa in the presence of folic acid and glycine. The peak potentials recorded in a phosphate buffer solution (PBS) of pH7.0 were 325, 750 and 880 mV vs. Ag/AgCl/KCl (3.0M) for methyldopa, folic acid and glycine, respectively. Under the optimum pH of 7.0, the oxidation of methyldopa occurred at a potential about 160 mV less positive than that of the unmodified carbon paste electrode (CPE). The response of catalytic current with methyldopa concentration showed a linear relation in the range from 2.0×10(-7) to 1.0×10(-4)M with a detection limit of 8.0 (± 0.2)×10(-8)M.
在这项研究中，使用 TiO2 纳米粒子和二茂铁羧酸（FM）修饰的碳糊电极制备了一种新型电化学传感器。这种新型电极修饰的目的是寻求检测甲基多巴的新电化学性能，同时存在叶酸和甘氨酸。在 pH7.0 的磷酸盐缓冲溶液（PBS）中记录的峰电位分别为 325、750 和 880 mV 相对于 Ag/AgCl/KCl（3.0M），分别为甲基多巴、叶酸和甘氨酸。在最佳 pH7.0 下，甲基多巴的氧化发生在比未修饰的碳糊电极（CPE）正约 160 mV 的电位。催化电流的响应与甲基多巴浓度呈线性关系，范围从 2.0×10(-7) 到 1.0×10(-4)M，检测限为 8.0（±0.2）×10(-8)M。
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