Beitollahi Hadi, Hamzavi Mozhdeh, Torkzadeh-Mahani Masoud
Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.
Mater Sci Eng C Mater Biol Appl. 2015;52:297-305. doi: 10.1016/j.msec.2015.03.031. Epub 2015 Mar 24.
A new ferrocene-derivative compound, 2-chlorobenzoyl ferrocene, was synthesized and used to construct a modified graphene oxide sheet paste electrode. The electrooxidation of hydrochlorothiazide at the surface of the modified electrode was studied. Under optimized conditions, the square wave voltammetric (SWV) peak current of hydrochlorothiazide increased linearly with hydrochlorothiazide concentration in the range of 5.0 × 10(-8) to 2.0 × 10(-4) M and a detection limit of 20.0 nM was obtained for hydrochlorothiazide. The diffusion coefficient and kinetic parameters (such as electron transfer coefficient and the heterogeneous rate constant) for hydrochlorothiazide oxidation were also determined. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of hydrochlorothiazide and folic acid which makes it suitable for the detection of hydrochlorothiazide in the presence of folic acid in real samples.
合成了一种新型二茂铁衍生物化合物2-氯苯甲酰基二茂铁，并将其用于构建修饰的氧化石墨烯片糊电极。研究了氢氯噻嗪在修饰电极表面的电氧化。在优化条件下，氢氯噻嗪的方波伏安（SWV）峰电流在5.0×10⁻⁸至2.0×10⁻⁴M范围内随氢氯噻嗪浓度呈线性增加，氢氯噻嗪的检测限为20.0 nM。还测定了氢氯噻嗪氧化的扩散系数和动力学参数（如电子转移系数和异相速率常数）。所制备的修饰电极在氢氯噻嗪和叶酸的伏安峰之间表现出很好的分辨率，这使得它适用于在实际样品中存在叶酸的情况下检测氢氯噻嗪。
